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Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease.
Ameen M, Sundaram L, Shen M, Banerjee A, Kundu S, Nair S, Shcherbina A, Gu M, Wilson KD, Varadarajan A, Vadgama N, Balsubramani A, Wu JC, Engreitz JM, Farh K, Karakikes I, Wang KC, Quertermous T, Greenleaf WJ, Kundaje A. Ameen M, et al. Among authors: wang kc. Cell. 2022 Dec 22;185(26):4937-4953.e23. doi: 10.1016/j.cell.2022.11.028. Cell. 2022. PMID: 36563664 Free PMC article.
Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy.
Sayed N, Liu C, Ameen M, Himmati F, Zhang JZ, Khanamiri S, Moonen JR, Wnorowski A, Cheng L, Rhee JW, Gaddam S, Wang KC, Sallam K, Boyd JH, Woo YJ, Rabinovitch M, Wu JC. Sayed N, et al. Among authors: wang kc. Sci Transl Med. 2020 Jul 29;12(554):eaax9276. doi: 10.1126/scitranslmed.aax9276. Sci Transl Med. 2020. PMID: 32727917 Free PMC article.
Modeling Effects of Immunosuppressive Drugs on Human Hearts Using Induced Pluripotent Stem Cell-Derived Cardiac Organoids and Single-Cell RNA Sequencing.
Sallam K, Thomas D, Gaddam S, Lopez N, Beck A, Beach L, Rogers AJ, Zhang H, Chen IY, Ameen M, Hiesinger W, Teuteberg JJ, Rhee JW, Wang KC, Sayed N, Wu JC. Sallam K, et al. Among authors: wang kc. Circulation. 2022 Apr 26;145(17):1367-1369. doi: 10.1161/CIRCULATIONAHA.121.054317. Epub 2022 Apr 25. Circulation. 2022. PMID: 35467958 Free PMC article. No abstract available.
Identification of constrained sequence elements across 239 primate genomes.
Kuderna LFK, Ulirsch JC, Rashid S, Ameen M, Sundaram L, Hickey G, Cox AJ, Gao H, Kumar A, Aguet F, Christmas MJ, Clawson H, Haeussler M, Janiak MC, Kuhlwilm M, Orkin JD, Bataillon T, Manu S, Valenzuela A, Bergman J, Rouselle M, Silva FE, Agueda L, Blanc J, Gut M, de Vries D, Goodhead I, Harris RA, Raveendran M, Jensen A, Chuma IS, Horvath JE, Hvilsom C, Juan D, Frandsen P, Schraiber JG, de Melo FR, Bertuol F, Byrne H, Sampaio I, Farias I, Valsecchi J, Messias M, da Silva MNF, Trivedi M, Rossi R, Hrbek T, Andriaholinirina N, Rabarivola CJ, Zaramody A, Jolly CJ, Phillips-Conroy J, Wilkerson G, Abee C, Simmons JH, Fernandez-Duque E, Kanthaswamy S, Shiferaw F, Wu D, Zhou L, Shao Y, Zhang G, Keyyu JD, Knauf S, Le MD, Lizano E, Merker S, Navarro A, Nadler T, Khor CC, Lee J, Tan P, Lim WK, Kitchener AC, Zinner D, Gut I, Melin AD, Guschanski K, Schierup MH, Beck RMD, Karakikes I, Wang KC, Umapathy G, Roos C, Boubli JP, Siepel A, Kundaje A, Paten B, Lindblad-Toh K, Rogers J, Marques Bonet T, Farh KK. Kuderna LFK, et al. Among authors: wang kc. Nature. 2024 Jan;625(7996):735-742. doi: 10.1038/s41586-023-06798-8. Epub 2023 Nov 29. Nature. 2024. PMID: 38030727 Free PMC article.
Epigenomics: Technologies and Applications.
Wang KC, Chang HY. Wang KC, et al. Circ Res. 2018 Apr 27;122(9):1191-1199. doi: 10.1161/CIRCRESAHA.118.310998. Circ Res. 2018. PMID: 29700067 Free PMC article. Review.
Molecular mechanisms of long noncoding RNAs.
Wang KC, Chang HY. Wang KC, et al. Mol Cell. 2011 Sep 16;43(6):904-14. doi: 10.1016/j.molcel.2011.08.018. Mol Cell. 2011. PMID: 21925379 Free PMC article. Review.
CRISPR-Mediated Reorganization of Chromatin Loop Structure.
Morgan SL, Chang EY, Mariano NC, Bermudez A, Arruda NL, Wu F, Luo Y, Shankar G, Huynh SK, Huang CC, Pitteri SJ, Wang KC. Morgan SL, et al. Among authors: wang kc. J Vis Exp. 2018 Sep 14;(139):57457. doi: 10.3791/57457. J Vis Exp. 2018. PMID: 30272647 Free PMC article.
1,111 results