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PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.
Sui L, Wang S, Ganguly D, El Rayes TP, Askeland C, Børretzen A, Sim D, Halvorsen OJ, Knutsvik G, Arnes J, Aziz S, Haukaas S, Foulkes WD, Bielenberg DR, Ziemys A, Mittal V, Brekken RA, Akslen LA, Watnick RS. Sui L, et al. Among authors: brekken ra. Nat Commun. 2022 Dec 27;13(1):7959. doi: 10.1038/s41467-022-35649-9. Nat Commun. 2022. PMID: 36575174 Free PMC article.
2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy.
Zhu D, Huang H, Pinkas DM, Luo J, Ganguly D, Fox AE, Arner E, Xiang Q, Tu ZC, Bullock AN, Brekken RA, Ding K, Lu X. Zhu D, et al. Among authors: brekken ra. J Med Chem. 2019 Aug 22;62(16):7431-7444. doi: 10.1021/acs.jmedchem.9b00365. Epub 2019 Aug 2. J Med Chem. 2019. PMID: 31310125 Free PMC article.
AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells.
Lotsberg ML, Wnuk-Lipinska K, Terry S, Tan TZ, Lu N, Trachsel-Moncho L, Røsland GV, Siraji MI, Hellesøy M, Rayford A, Jacobsen K, Ditzel HJ, Vintermyr OK, Bivona TG, Minna J, Brekken RA, Baguley B, Micklem D, Akslen LA, Gausdal G, Simonsen A, Thiery JP, Chouaib S, Lorens JB, Engelsen AST. Lotsberg ML, et al. Among authors: brekken ra. J Thorac Oncol. 2020 Jun;15(6):973-999. doi: 10.1016/j.jtho.2020.01.015. Epub 2020 Feb 1. J Thorac Oncol. 2020. PMID: 32018052 Free PMC article.
Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment.
Ganguly D, Chandra R, Karalis J, Teke M, Aguilera T, Maddipati R, Wachsmann MB, Ghersi D, Siravegna G, Zeh HJ 3rd, Brekken R, Ting DT, Ligorio M. Ganguly D, et al. Cancers (Basel). 2020 Sep 17;12(9):2652. doi: 10.3390/cancers12092652. Cancers (Basel). 2020. PMID: 32957515 Free PMC article. Review.
AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer.
Engelsen AST, Wnuk-Lipinska K, Bougnaud S, Pelissier Vatter FA, Tiron C, Villadsen R, Miyano M, Lotsberg ML, Madeleine N, Panahandeh P, Dhakal S, Tan TZ, Peters SD, Grøndal S, Aziz SM, Nord S, Herfindal L, Stampfer MR, Sørlie T, Brekken RA, Straume O, Halberg N, Gausdal G, Thiery JP, Akslen LA, Petersen OW, LaBarge MA, Lorens JB. Engelsen AST, et al. Among authors: brekken ra. iScience. 2020 Oct 7;23(11):101649. doi: 10.1016/j.isci.2020.101649. eCollection 2020 Nov 20. iScience. 2020. PMID: 33103086 Free PMC article.
223 results