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Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease.
Varma VR, Desai RJ, Navakkode S, Wong LW, Anerillas C, Loeffler T, Schilcher I, Mahesri M, Chin K, Horton DB, Kim SC, Gerhard T, Segal JB, Schneeweiss S, Gorospe M, Sajikumar S, Thambisetty M. Varma VR, et al. Among authors: gorospe m. Mol Psychiatry. 2023 Mar;28(3):1312-1326. doi: 10.1038/s41380-022-01912-0. Epub 2022 Dec 28. Mol Psychiatry. 2023. PMID: 36577843 Free PMC article.
Regulation of senescence traits by MAPKs.
Anerillas C, Abdelmohsen K, Gorospe M. Anerillas C, et al. Among authors: gorospe m. Geroscience. 2020 Apr;42(2):397-408. doi: 10.1007/s11357-020-00183-3. Epub 2020 Apr 16. Geroscience. 2020. PMID: 32300964 Free PMC article. Review.
Translational Control during Cellular Senescence.
Payea MJ, Anerillas C, Tharakan R, Gorospe M. Payea MJ, et al. Among authors: gorospe m. Mol Cell Biol. 2021 Jan 25;41(2):e00512-20. doi: 10.1128/MCB.00512-20. Print 2021 Jan 25. Mol Cell Biol. 2021. PMID: 33077499 Free PMC article. Review.
Acid ceramidase promotes senescent cell survival.
Munk R, Anerillas C, Rossi M, Tsitsipatis D, Martindale JL, Herman AB, Yang JH, Roberts JA, Varma VR, Pandey PR, Thambisetty M, Gorospe M, Abdelmohsen K. Munk R, et al. Among authors: gorospe m. Aging (Albany NY). 2021 Jun 8;13(12):15750-15769. doi: 10.18632/aging.203170. Epub 2021 Jun 8. Aging (Albany NY). 2021. PMID: 34102611 Free PMC article.
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.
Herman AB, Anerillas C, Harris SC, Munk R, Martindale JL, Yang X, Mazan-Mamczarz K, Zhang Y, Heckenbach IJ, Scheibye-Knudsen M, De S, Sen P, Abdelmohsen K, Gorospe M. Herman AB, et al. Among authors: gorospe m. Nucleic Acids Res. 2021 Jul 21;49(13):7389-7405. doi: 10.1093/nar/gkab538. Nucleic Acids Res. 2021. PMID: 34181735 Free PMC article.
Systematic Identification of circRNAs in Alzheimer's Disease.
Cochran KR, Veeraraghavan K, Kundu G, Mazan-Mamczarz K, Coletta C, Thambisetty M, Gorospe M, De S. Cochran KR, et al. Among authors: gorospe m. Genes (Basel). 2021 Aug 18;12(8):1258. doi: 10.3390/genes12081258. Genes (Basel). 2021. PMID: 34440432 Free PMC article.
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.
Roberts JA, Varma VR, An Y, Varma S, Candia J, Fantoni G, Tiwari V, Anerillas C, Williamson A, Saito A, Loeffler T, Schilcher I, Moaddel R, Khadeer M, Lovett J, Tanaka T, Pletnikova O, Troncoso JC, Bennett DA, Albert MS, Yu K, Niu M, Haroutunian V, Zhang B, Peng J, Croteau DL, Resnick SM, Gorospe M, Bohr VA, Ferrucci L, Thambisetty M. Roberts JA, et al. Among authors: gorospe m. Sci Adv. 2021 Nov 12;7(46):eabi8178. doi: 10.1126/sciadv.abi8178. Epub 2021 Nov 10. Sci Adv. 2021. PMID: 34757788 Free PMC article.
Early SRC activation skews cell fate from apoptosis to senescence.
Anerillas C, Herman AB, Rossi M, Munk R, Lehrmann E, Martindale JL, Cui CY, Abdelmohsen K, De S, Gorospe M. Anerillas C, et al. Among authors: gorospe m. Sci Adv. 2022 Apr 8;8(14):eabm0756. doi: 10.1126/sciadv.abm0756. Epub 2022 Apr 8. Sci Adv. 2022. PMID: 35394839 Free PMC article.
A BDNF-TrkB autocrine loop enhances senescent cell viability.
Anerillas C, Herman AB, Munk R, Garrido A, Lam KG, Payea MJ, Rossi M, Tsitsipatis D, Martindale JL, Piao Y, Mazan-Mamczarz K, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. Anerillas C, et al. Among authors: gorospe m. Nat Commun. 2022 Oct 20;13(1):6228. doi: 10.1038/s41467-022-33709-8. Nat Commun. 2022. PMID: 36266274 Free PMC article.
Author Correction: A BDNF-TrkB autocrine loop enhances senescent cell viability.
Anerillas C, Herman AB, Munk R, Garrido A, Lam KG, Payea MJ, Rossi M, Tsitsipatis D, Martindale JL, Piao Y, Mazan-Mamczarz K, Fan J, Cui CY, De S, Abdelmohsen K, de Cabo R, Gorospe M. Anerillas C, et al. Among authors: gorospe m. Nat Commun. 2022 Dec 7;13(1):7540. doi: 10.1038/s41467-022-35154-z. Nat Commun. 2022. PMID: 36477003 Free PMC article. No abstract available.
461 results