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Page 1
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease.
Varma VR, Desai RJ, Navakkode S, Wong LW, Anerillas C, Loeffler T, Schilcher I, Mahesri M, Chin K, Horton DB, Kim SC, Gerhard T, Segal JB, Schneeweiss S, Gorospe M, Sajikumar S, Thambisetty M. Varma VR, et al. Among authors: loeffler t. Mol Psychiatry. 2023 Mar;28(3):1312-1326. doi: 10.1038/s41380-022-01912-0. Epub 2022 Dec 28. Mol Psychiatry. 2023. PMID: 36577843 Free PMC article.
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.
Roberts JA, Varma VR, An Y, Varma S, Candia J, Fantoni G, Tiwari V, Anerillas C, Williamson A, Saito A, Loeffler T, Schilcher I, Moaddel R, Khadeer M, Lovett J, Tanaka T, Pletnikova O, Troncoso JC, Bennett DA, Albert MS, Yu K, Niu M, Haroutunian V, Zhang B, Peng J, Croteau DL, Resnick SM, Gorospe M, Bohr VA, Ferrucci L, Thambisetty M. Roberts JA, et al. Among authors: loeffler t. Sci Adv. 2021 Nov 12;7(46):eabi8178. doi: 10.1126/sciadv.abi8178. Epub 2021 Nov 10. Sci Adv. 2021. PMID: 34757788 Free PMC article.
No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer's disease and related dementia: results from the Drug Repurposing for Effective Alzheimer's Medicines study.
Desai RJ, Mahesri M, Lee SB, Varma VR, Loeffler T, Schilcher I, Gerhard T, Segal JB, Ritchey ME, Horton DB, Kim SC, Schneeweiss S, Thambisetty M. Desai RJ, et al. Among authors: loeffler t. Brain Commun. 2022 Oct 4;4(5):fcac247. doi: 10.1093/braincomms/fcac247. eCollection 2022. Brain Commun. 2022. PMID: 36330433 Free PMC article.
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation.
Babalola JA, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G. Babalola JA, et al. Among authors: loeffler t. Brain Res. 2023 Nov 15;1819:148518. doi: 10.1016/j.brainres.2023.148518. Epub 2023 Aug 12. Brain Res. 2023. PMID: 37579986 Free article.
Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice.
Babalola JA, Stracke A, Loeffler T, Schilcher I, Spyridon S, Flunkert S, Neddens J, Lignell A, Prokesch M, Pazenboeck U, Strobl H, Tadic J, Leitinger G, Lass A, Hutter-Paier B, Hoefler G. Babalola JA, et al. Among authors: loeffler t. Mol Metab. 2024 May 17;85:101959. doi: 10.1016/j.molmet.2024.101959. Online ahead of print. Mol Metab. 2024. PMID: 38763496 Free article.
Constant Levels of Tau Phosphorylation in the Brain of htau Mice.
Neddens J, Daurer M, Loeffler T, Alzola Aldamizetxebarria S, Flunkert S, Hutter-Paier B. Neddens J, et al. Among authors: loeffler t. Front Mol Neurosci. 2020 Aug 28;13:136. doi: 10.3389/fnmol.2020.00136. eCollection 2020. Front Mol Neurosci. 2020. PMID: 32982685 Free PMC article.
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Neddens J, Temmel M, Flunkert S, Kerschbaumer B, Hoeller C, Loeffler T, Niederkofler V, Daum G, Attems J, Hutter-Paier B. Neddens J, et al. Among authors: loeffler t. Acta Neuropathol Commun. 2018 Jun 29;6(1):52. doi: 10.1186/s40478-018-0557-6. Acta Neuropathol Commun. 2018. PMID: 29958544 Free PMC article.
53 results