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Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain.
bioRxiv [Preprint]. 2024 Mar 27:2024.03.21.585809. doi: 10.1101/2024.03.21.585809.
bioRxiv. 2024.
PMID: 38585983
Free PMC article.
Preprint.
Pathogenic variants in CRX have distinct cis-regulatory effects on enhancers and silencers in photoreceptors.
Shepherdson JL, Friedman RZ, Zheng Y, Sun C, Oh IY, Granas DM, Cohen BA, Chen S, White MA.
Shepherdson JL, et al. Among authors: granas dm.
Genome Res. 2024 Mar 20;34(2):243-255. doi: 10.1101/gr.278133.123.
Genome Res. 2024.
PMID: 38355306
Free PMC article.
Item in Clipboard
Active learning of enhancer and silencer regulatory grammar in photoreceptors.
Friedman RZ, Ramu A, Lichtarge S, Myers CA, Granas DM, Gause M, Corbo JC, Cohen BA, White MA.
Friedman RZ, et al. Among authors: granas dm.
bioRxiv [Preprint]. 2023 Aug 22:2023.08.21.554146. doi: 10.1101/2023.08.21.554146.
bioRxiv. 2023.
PMID: 37662358
Free PMC article.
Preprint.
Item in Clipboard
Pathogenic variants in Crx have distinct cis-regulatory effects on enhancers and silencers in photoreceptors.
Shepherdson JL, Friedman RZ, Zheng Y, Sun C, Oh IY, Granas DM, Cohen BA, Chen S, White MA.
Shepherdson JL, et al. Among authors: granas dm.
bioRxiv [Preprint]. 2023 Dec 2:2023.05.27.542576. doi: 10.1101/2023.05.27.542576.
bioRxiv. 2023.
PMID: 37292699
Free PMC article.
Updated.
Preprint.
Item in Clipboard
A single-cell massively parallel reporter assay detects cell-type-specific gene regulation.
Zhao S, Hong CKY, Myers CA, Granas DM, White MA, Corbo JC, Cohen BA.
Zhao S, et al. Among authors: granas dm.
Nat Genet. 2023 Feb;55(2):346-354. doi: 10.1038/s41588-022-01278-7. Epub 2023 Jan 12.
Nat Genet. 2023.
PMID: 36635387
Free PMC article.
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Information content differentiates enhancers from silencers in mouse photoreceptors.
Friedman RZ, Granas DM, Myers CA, Corbo JC, Cohen BA, White MA.
Friedman RZ, et al. Among authors: granas dm.
Elife. 2021 Sep 6;10:e67403. doi: 10.7554/eLife.67403.
Elife. 2021.
PMID: 34486522
Free PMC article.
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Synthetic and genomic regulatory elements reveal aspects of cis-regulatory grammar in mouse embryonic stem cells.
King DM, Hong CKY, Shepherdson JL, Granas DM, Maricque BB, Cohen BA.
King DM, et al. Among authors: granas dm.
Elife. 2020 Feb 11;9:e41279. doi: 10.7554/eLife.41279.
Elife. 2020.
PMID: 32043966
Free PMC article.
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Whole genome sequencing identifies a deletion in protein phosphatase 2A that affects its stability and localization in Chlamydomonas reinhardtii.
Lin H, Miller ML, Granas DM, Dutcher SK.
Lin H, et al. Among authors: granas dm.
PLoS Genet. 2013;9(9):e1003841. doi: 10.1371/journal.pgen.1003841. Epub 2013 Sep 26.
PLoS Genet. 2013.
PMID: 24086163
Free PMC article.
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