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Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, Bartels T, Nuber S, Sulzer D, Mosharov EV, Chen WV, Li S, Selkoe DJ, Dettmer U. Ramalingam N, et al. Among authors: bartels t. NPJ Parkinsons Dis. 2023 Jan 16;9(1):4. doi: 10.1038/s41531-023-00444-w. NPJ Parkinsons Dis. 2023. PMID: 36646701 Free PMC article.
Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.
Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Dettmer U, et al. Among authors: bartels t. Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227. Hum Mol Genet. 2017. PMID: 28911198 Free PMC article.
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. Dettmer U, et al. Among authors: bartels t. J Biol Chem. 2013 Mar 1;288(9):6371-85. doi: 10.1074/jbc.M112.403311. Epub 2013 Jan 14. J Biol Chem. 2013. PMID: 23319586 Free PMC article.
We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicles more avidly than unfolded recombinant monomers (Bartels, T., Choi, J. G., and Selkoe, D. J. (2011) Nature 477, 107-110). Ho …
We recently reported that alphaSyn can instead exist in cells as a helically folded tetramer that resists aggregation and binds lipid vesicl …
Defining the native state of α-synuclein.
Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Selkoe D, et al. Among authors: bartels t. Neurodegener Dis. 2014;13(2-3):114-7. doi: 10.1159/000355516. Epub 2013 Oct 30. Neurodegener Dis. 2014. PMID: 24192542 Review.
ExPLAining early synucleinopathies.
Dettmer U, Bartels T. Dettmer U, et al. Among authors: bartels t. Brain. 2015 Jun;138(Pt 6):1449-51. doi: 10.1093/brain/awv099. Brain. 2015. PMID: 26013805 Free PMC article.
167 results