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Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders.
Burglen L, Van Hoeymissen E, Qebibo L, Barth M, Belnap N, Boschann F, Depienne C, De Clercq K, Douglas AGL, Fitzgerald MP, Foulds N, Garel C, Helbig I, Held K, Horn D, Janssen A, Kaindl AM, Narayanan V, Prager C, Rupin-Mas M, Afenjar A, Zhao S, Ramaekers VT, Ruggiero SM, Thomas S, Valence S, Van Maldergem L, Rohacs T, Rodriguez D, Dyment D, Voets T, Vriens J. Burglen L, et al. Among authors: de clercq k. Elife. 2023 Jan 17;12:e81032. doi: 10.7554/eLife.81032. Elife. 2023. PMID: 36648066 Free PMC article.
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, Marchand A, Reeh PW, Chaltin P, Voets T, Vriens J. Held K, et al. Among authors: de clercq k. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1363-72. doi: 10.1073/pnas.1419845112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733887 Free PMC article.
A TRP channel trio mediates acute noxious heat sensing.
Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T. Vandewauw I, et al. Among authors: de clercq k. Nature. 2018 Mar 29;555(7698):662-666. doi: 10.1038/nature26137. Epub 2018 Mar 14. Nature. 2018. PMID: 29539642
Functional expression of the mechanosensitive PIEZO1 channel in primary endometrial epithelial cells and endometrial organoids.
Hennes A, Held K, Boretto M, De Clercq K, Van den Eynde C, Vanhie A, Van Ranst N, Benoit M, Luyten C, Peeraer K, Tomassetti C, Meuleman C, Voets T, Vankelecom H, Vriens J. Hennes A, et al. Among authors: de clercq k. Sci Rep. 2019 Feb 11;9(1):1779. doi: 10.1038/s41598-018-38376-8. Sci Rep. 2019. PMID: 30741991 Free PMC article.
203 results