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Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders.
Burglen L, Van Hoeymissen E, Qebibo L, Barth M, Belnap N, Boschann F, Depienne C, De Clercq K, Douglas AGL, Fitzgerald MP, Foulds N, Garel C, Helbig I, Held K, Horn D, Janssen A, Kaindl AM, Narayanan V, Prager C, Rupin-Mas M, Afenjar A, Zhao S, Ramaekers VT, Ruggiero SM, Thomas S, Valence S, Van Maldergem L, Rohacs T, Rodriguez D, Dyment D, Voets T, Vriens J. Burglen L, et al. Among authors: held k. Elife. 2023 Jan 17;12:e81032. doi: 10.7554/eLife.81032. Elife. 2023. PMID: 36648066 Free PMC article.
Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release.
Held K, Kichko T, De Clercq K, Klaassen H, Van Bree R, Vanherck JC, Marchand A, Reeh PW, Chaltin P, Voets T, Vriens J. Held K, et al. Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1363-72. doi: 10.1073/pnas.1419845112. Epub 2015 Mar 2. Proc Natl Acad Sci U S A. 2015. PMID: 25733887 Free PMC article.
TRPM3 in temperature sensing and beyond.
Held K, Voets T, Vriens J. Held K, et al. Temperature (Austin). 2015 Feb 25;2(2):201-13. doi: 10.4161/23328940.2014.988524. eCollection 2015 Apr-Jun. Temperature (Austin). 2015. PMID: 27227024 Free PMC article. Review.
A TRP channel trio mediates acute noxious heat sensing.
Vandewauw I, De Clercq K, Mulier M, Held K, Pinto S, Van Ranst N, Segal A, Voet T, Vennekens R, Zimmermann K, Vriens J, Voets T. Vandewauw I, et al. Among authors: held k. Nature. 2018 Mar 29;555(7698):662-666. doi: 10.1038/nature26137. Epub 2018 Mar 14. Nature. 2018. PMID: 29539642
440 results