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Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.
Iqbal F, Schlotter F, Becker-Greene D, Lupieri A, Goettsch C, Hutcheson JD, Rogers MA, Itoh S, Halu A, Lee LH, Blaser MC, Mlynarchik AK, Hagita S, Kuraoka S, Chen HY, Engert JC, Passos LSA, Jha PK, Osborn EA, Jaffer FA, Body SC, Robson SC, Thanassoulis G, Aikawa M, Singh SA, Sonawane AR, Aikawa E. Iqbal F, et al. Among authors: halu a. Eur Heart J. 2023 Mar 7;44(10):885-898. doi: 10.1093/eurheartj/ehac818. Eur Heart J. 2023. PMID: 36660854 Free PMC article.
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. Iwata H, et al. Among authors: halu a. Nat Commun. 2016 Oct 31;7:12849. doi: 10.1038/ncomms12849. Nat Commun. 2016. PMID: 27796300 Free PMC article.
Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Schlotter F, et al. Among authors: halu a. Circulation. 2018 Jul 24;138(4):377-393. doi: 10.1161/CIRCULATIONAHA.117.032291. Circulation. 2018. PMID: 29588317 Free PMC article.
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A. Halu A, et al. Elife. 2018 Oct 10;7:e37059. doi: 10.7554/eLife.37059. Elife. 2018. PMID: 30303482 Free PMC article.
Many different proteins interact with each other to control inflammation; gaining an insight into the nature of these interactions could help to pinpoint the role of each molecular actor. Researchers have used a combination of unbiased, large-scale experimental and computa …
Many different proteins interact with each other to control inflammation; gaining an insight into the nature of these interactions could hel …
Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.
Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Nakano T, et al. Among authors: halu a. Circulation. 2019 Jan 2;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588. Circulation. 2019. PMID: 30586693 Free PMC article.
Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.
Rogers MA, Buffolo F, Schlotter F, Atkins SK, Lee LH, Halu A, Blaser MC, Tsolaki E, Higashi H, Luther K, Daaboul G, Bouten CVC, Body SC, Singh SA, Bertazzo S, Libby P, Aikawa M, Aikawa E. Rogers MA, et al. Among authors: halu a. Sci Adv. 2020 Sep 16;6(38):eabb1244. doi: 10.1126/sciadv.abb1244. Print 2020 Sep. Sci Adv. 2020. PMID: 32938681 Free PMC article.
ApoC-III is a novel inducer of calcification in human aortic valves.
Schlotter F, de Freitas RCC, Rogers MA, Blaser MC, Wu PJ, Higashi H, Halu A, Iqbal F, Andraski AB, Rodia CN, Kuraoka S, Wen JR, Creager M, Pham T, Hutcheson JD, Body SC, Kohan AB, Sacks FM, Aikawa M, Singh SA, Aikawa E. Schlotter F, et al. Among authors: halu a. J Biol Chem. 2021 Jan-Jun;296:100193. doi: 10.1074/jbc.RA120.015700. Epub 2021 Jan 6. J Biol Chem. 2021. PMID: 33334888 Free PMC article.
44 results