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Mammalian life depends on two distinct pathways of DNA damage tolerance.
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2216055120. doi: 10.1073/pnas.2216055120. Epub 2023 Jan 20.
Proc Natl Acad Sci U S A. 2023.
PMID: 36669105
Free PMC article.
Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.
Spanjaard A, Shah R, de Groot D, Buoninfante OA, Morris B, Lieftink C, Pritchard C, Zürcher LM, Ormel S, Catsman JJI, de Korte-Grimmerink R, Siteur B, Proost N, Boadum T, van de Ven M, Song JY, Kreft M, van den Berk PCM, Beijersbergen RL, Jacobs H.
Spanjaard A, et al. Among authors: buoninfante oa.
Nucleic Acids Res. 2022 Jul 22;50(13):7420-7435. doi: 10.1093/nar/gkac545.
Nucleic Acids Res. 2022.
PMID: 35819193
Free PMC article.
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The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
Will Castro LSEP, Pieters W, Alemdehy MF, Aslam MA, Buoninfante OA, Raaijmakers JA, Pilzecker B, van den Berk PCM, Te Riele H, Medema RH, Pedrosa RC, Jacobs H.
Will Castro LSEP, et al. Among authors: buoninfante oa.
Front Pharmacol. 2021 Feb 18;12:596535. doi: 10.3389/fphar.2021.596535. eCollection 2021.
Front Pharmacol. 2021.
PMID: 33679394
Free PMC article.
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DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy.
Pilzecker B, Buoninfante OA, Jacobs H.
Pilzecker B, et al. Among authors: buoninfante oa.
Nucleic Acids Res. 2019 Aug 22;47(14):7163-7181. doi: 10.1093/nar/gkz531.
Nucleic Acids Res. 2019.
PMID: 31251805
Free PMC article.
Review.
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Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system.
Buoninfante OA, Pilzecker B, Aslam MA, Zavrakidis I, van der Wiel R, van de Ven M, van den Berk PCM, Jacobs H.
Buoninfante OA, et al.
Oncotarget. 2018 Apr 10;9(27):18832-18843. doi: 10.18632/oncotarget.24777. eCollection 2018 Apr 10.
Oncotarget. 2018.
PMID: 29721165
Free PMC article.
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DNA damage tolerance in hematopoietic stem and progenitor cells in mice.
Pilzecker B, Buoninfante OA, van den Berk P, Lancini C, Song JY, Citterio E, Jacobs H.
Pilzecker B, et al. Among authors: buoninfante oa.
Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6875-E6883. doi: 10.1073/pnas.1706508114. Epub 2017 Jul 31.
Proc Natl Acad Sci U S A. 2017.
PMID: 28761001
Free PMC article.
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PrimPol prevents APOBEC/AID family mediated DNA mutagenesis.
Pilzecker B, Buoninfante OA, Pritchard C, Blomberg OS, Huijbers IJ, van den Berk PC, Jacobs H.
Pilzecker B, et al. Among authors: buoninfante oa.
Nucleic Acids Res. 2016 Jun 2;44(10):4734-44. doi: 10.1093/nar/gkw123. Epub 2016 Feb 28.
Nucleic Acids Res. 2016.
PMID: 26926109
Free PMC article.
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Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage.
Wit N, Buoninfante OA, van den Berk PC, Jansen JG, Hogenbirk MA, de Wind N, Jacobs H.
Wit N, et al. Among authors: buoninfante oa.
Nucleic Acids Res. 2015 Jan;43(1):282-94. doi: 10.1093/nar/gku1301. Epub 2014 Dec 10.
Nucleic Acids Res. 2015.
PMID: 25505145
Free PMC article.
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