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Large language models generate functional protein sequences across diverse families.
Madani A, Krause B, Greene ER, Subramanian S, Mohr BP, Holton JM, Olmos JL Jr, Xiong C, Sun ZZ, Socher R, Fraser JS, Naik N. Madani A, et al. Among authors: subramanian s. Nat Biotechnol. 2023 Aug;41(8):1099-1106. doi: 10.1038/s41587-022-01618-2. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702895 Free PMC article.
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM.
Marcus K, Huang Y, Subramanian S, Gee CL, Gorday K, Ghaffari-Kashani S, Luo XR, Zheng L, O'Donnell M, Subramaniam S, Kuriyan J. Marcus K, et al. Among authors: subramanian s. Nat Struct Mol Biol. 2024 Mar;31(3):424-435. doi: 10.1038/s41594-023-01177-3. Epub 2024 Jan 4. Nat Struct Mol Biol. 2024. PMID: 38177685 Free PMC article.
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.
Yang K, Wang C, Kreutzberger AJB, Ojha R, Kuivanen S, Couoh-Cardel S, Muratcioglu S, Eisen TJ, White KI, Held RG, Subramanian S, Marcus K, Pfuetzner RA, Esquivies L, Doyle CA, Kuriyan J, Vapalahti O, Balistreri G, Kirchhausen T, Brunger AT. Yang K, et al. Among authors: subramanian s. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2210990119. doi: 10.1073/pnas.2210990119. Epub 2022 Sep 19. Proc Natl Acad Sci U S A. 2022. PMID: 36122200 Free PMC article.
Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.
Kudira R, Yang ZF, Osuji I, Karns R, Bariya P, Pfuhler L, Mullen M, Taylor A, Ji H, Lages CS, Yang Vom Hofe A, Shi T, Pasula S, Wayman JA, Bernieh A, Zhang W, Chougnet CA, Hildeman D, Tiao GM, Huppert SS, Subramanian S, Salomonis N, Miraldi E, Miethke AG. Kudira R, et al. Among authors: subramanian s. bioRxiv [Preprint]. 2024 May 21:2024.05.17.594680. doi: 10.1101/2024.05.17.594680. bioRxiv. 2024. PMID: 38826326 Free PMC article. Preprint.
Path to autonomous soil sampling and analysis by ground-based robots.
Norby J, Wang S, Wang H, Deng S, Jones N, Mishra A, Pavlov C, He H, Subramanian S, Thangavelu V, Sihota N, Hoelen T, Johnson AM, Lowry GV. Norby J, et al. Among authors: subramanian s. J Environ Manage. 2024 Jun;360:121130. doi: 10.1016/j.jenvman.2024.121130. Epub 2024 May 20. J Environ Manage. 2024. PMID: 38772232 Free article.
3,280 results