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APOBEC mutagenesis is a common process in normal human small intestine.
Wang Y, Robinson PS, Coorens THH, Moore L, Lee-Six H, Noorani A, Sanders MA, Jung H, Katainen R, Heuschkel R, Brunton-Sim R, Weston R, Read D, Nobbs B, Fitzgerald RC, Saeb-Parsy K, Martincorena I, Campbell PJ, Rushbrook S, Zilbauer M, Buczacki SJA, Stratton MR. Wang Y, et al. Among authors: brunton sim r. Nat Genet. 2023 Feb;55(2):246-254. doi: 10.1038/s41588-022-01296-5. Epub 2023 Jan 26. Nat Genet. 2023. PMID: 36702998 Free PMC article.
Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells.
Robinson PS, Thomas LE, Abascal F, Jung H, Harvey LMR, West HD, Olafsson S, Lee BCH, Coorens THH, Lee-Six H, Butlin L, Lander N, Truscott R, Sanders MA, Lensing SV, Buczacki SJA, Ten Hoopen R, Coleman N, Brunton-Sim R, Rushbrook S, Saeb-Parsy K, Lalloo F, Campbell PJ, Martincorena I, Sampson JR, Stratton MR. Robinson PS, et al. Among authors: brunton sim r. Nat Commun. 2022 Jul 8;13(1):3949. doi: 10.1038/s41467-022-31341-0. Nat Commun. 2022. PMID: 35803914 Free PMC article.
A Diffusion-like Process Accommodates New Crypts During Clonal Expansion in Human Colonic Epithelium.
Olpe C, Khamis D, Chukanova M, Skoufou-Papoutsaki N, Kemp R, Marks K, Tatton C, Lindskog C, Nicholson A, Brunton-Sim R, Malhotra S, Ten Hoopen R, Stanley R, Winton DJ, Morrissey E. Olpe C, et al. Among authors: brunton sim r. Gastroenterology. 2021 Aug;161(2):548-559.e23. doi: 10.1053/j.gastro.2021.04.035. Epub 2021 Apr 22. Gastroenterology. 2021. PMID: 33895166 Free PMC article.
Preliminary evaluation of a rapid lateral flow calprotectin test for the diagnosis of prosthetic joint infection.
Trotter AJ, Dean R, Whitehouse CE, Mikalsen J, Hill C, Brunton-Sim R, Kay GL, Shakokani M, Durst AZE, Wain J, McNamara I, O'Grady J. Trotter AJ, et al. Among authors: brunton sim r. Bone Joint Res. 2020 Jun 8;9(5):202-210. doi: 10.1302/2046-3758.95.BJR-2019-0213.R1. eCollection 2020 May. Bone Joint Res. 2020. PMID: 32566141 Free PMC article.
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Nicholson AM, Olpe C, Hoyle A, Thorsen AS, Rus T, Colombé M, Brunton-Sim R, Kemp R, Marks K, Quirke P, Malhotra S, Ten Hoopen R, Ibrahim A, Lindskog C, Myers MB, Parsons B, Tavaré S, Wilkinson M, Morrissey E, Winton DJ. Nicholson AM, et al. Among authors: brunton sim r. Cell Stem Cell. 2018 Jun 1;22(6):909-918.e8. doi: 10.1016/j.stem.2018.04.020. Epub 2018 May 17. Cell Stem Cell. 2018. PMID: 29779891 Free PMC article.