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Hemoglobin increases leukocyte adhesion and initiates lung microvascular endothelial activation via Toll-like receptor 4 signaling.
Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C665-C673. doi: 10.1152/ajpcell.00211.2022. Epub 2023 Jan 30.
Am J Physiol Cell Physiol. 2023.
PMID: 36717098
Free PMC article.
Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis.
Meegan JE, Komalavilas P, Cheung-Flynn J, Yim TW, Putz ND, Jesse JJ, Smith KD, Sidorova TN, Lee HNR, Tomasek T, Shaver CM, Ware LB, Brophy CM, Bastarache JA.
Meegan JE, et al. Among authors: tomasek t.
Physiol Rep. 2022 Jun;10(11):e15290. doi: 10.14814/phy2.15290.
Physiol Rep. 2022.
PMID: 35668576
Free PMC article.
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Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death.
Tomasek T, Ware LB, Bastarache JA, Meegan JE.
Tomasek T, et al.
Biochem Biophys Res Commun. 2021 Jun 4;556:199-206. doi: 10.1016/j.bbrc.2021.03.161. Epub 2021 Apr 10.
Biochem Biophys Res Commun. 2021.
PMID: 33848934
Free PMC article.
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