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The lack of Troponin I Ser-23/24 phosphorylation is detrimental to in vivo cardiac function and exacerbates cardiac disease.
J Mol Cell Cardiol. 2023 Mar;176:84-96. doi: 10.1016/j.yjmcc.2023.01.010. Epub 2023 Jan 29.
J Mol Cell Cardiol. 2023.
PMID: 36724829
Free PMC article.
The ABC transporter encoded at the pneumococcal fructooligosaccharide utilization locus determines the ability to utilize long- and short-chain fructooligosaccharides.
Linke CM, Woodiga SA, Meyers DJ, Buckwalter CM, Salhi HE, King SJ.
Linke CM, et al. Among authors: salhi he.
J Bacteriol. 2013 Mar;195(5):1031-41. doi: 10.1128/JB.01560-12. Epub 2012 Dec 21.
J Bacteriol. 2013.
PMID: 23264576
Free PMC article.
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Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.
Salhi HE, Walton SD, Hassel NC, Brundage EA, de Tombe PP, Janssen PM, Davis JP, Biesiadecki BJ.
Salhi HE, et al.
J Mol Cell Cardiol. 2014 Nov;76:257-64. doi: 10.1016/j.yjmcc.2014.09.013. Epub 2014 Sep 22.
J Mol Cell Cardiol. 2014.
PMID: 25252176
Free PMC article.
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Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.
Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP.
Shettigar V, et al. Among authors: salhi he.
Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794.
Nat Commun. 2016.
PMID: 26908229
Free PMC article.
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Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.
Salhi HE, Hassel NC, Siddiqui JK, Brundage EA, Ziolo MT, Janssen PM, Davis JP, Biesiadecki BJ.
Salhi HE, et al.
Front Physiol. 2016 Dec 15;7:567. doi: 10.3389/fphys.2016.00567. eCollection 2016.
Front Physiol. 2016.
PMID: 28018230
Free PMC article.
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Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I.
Siddiqui JK, Tikunova SB, Walton SD, Liu B, Meyer M, de Tombe PP, Neilson N, Kekenes-Huskey PM, Salhi HE, Janssen PM, Biesiadecki BJ, Davis JP.
Siddiqui JK, et al. Among authors: salhi he.
Front Physiol. 2016 Dec 21;7:632. doi: 10.3389/fphys.2016.00632. eCollection 2016.
Front Physiol. 2016.
PMID: 28066265
Free PMC article.
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Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis.
Martin-Garrido A, Biesiadecki BJ, Salhi HE, Shaifta Y, Dos Remedios CG, Ayaz-Guner S, Cai W, Ge Y, Avkiran M, Kentish JC.
Martin-Garrido A, et al. Among authors: salhi he.
J Biol Chem. 2018 Jun 1;293(22):8588-8599. doi: 10.1074/jbc.RA117.001292. Epub 2018 Apr 18.
J Biol Chem. 2018.
PMID: 29669813
Free PMC article.
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Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function.
Salyer LG, Salhi HE, Brundage EA, Shettigar V, Sturgill SL, Zanella H, Templeton B, Abay E, Emmer KM, Lowe J, Rafael-Fortney JA, Parinandi N, Foster DB, McKinsey TA, Woulfe KC, Ziolo MT, Biesiadecki BJ.
Salyer LG, et al. Among authors: salhi he.
Circ Res. 2024 Jan 5;134(1):33-45. doi: 10.1161/CIRCRESAHA.123.323132. Epub 2023 Dec 14.
Circ Res. 2024.
PMID: 38095088
Free article.
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