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Page 1
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease.
Shettigar V, Zhang B, Little SC, Salhi HE, Hansen BJ, Li N, Zhang J, Roof SR, Ho HT, Brunello L, Lerch JK, Weisleder N, Fedorov VV, Accornero F, Rafael-Fortney JA, Gyorke S, Janssen PM, Biesiadecki BJ, Ziolo MT, Davis JP. Shettigar V, et al. Among authors: salhi he. Nat Commun. 2016 Feb 24;7:10794. doi: 10.1038/ncomms10794. Nat Commun. 2016. PMID: 26908229 Free PMC article.
Monophosphorylation of cardiac troponin-I at Ser-23/24 is sufficient to regulate cardiac myofibrillar Ca2+ sensitivity and calpain-induced proteolysis.
Martin-Garrido A, Biesiadecki BJ, Salhi HE, Shaifta Y, Dos Remedios CG, Ayaz-Guner S, Cai W, Ge Y, Avkiran M, Kentish JC. Martin-Garrido A, et al. Among authors: salhi he. J Biol Chem. 2018 Jun 1;293(22):8588-8599. doi: 10.1074/jbc.RA117.001292. Epub 2018 Apr 18. J Biol Chem. 2018. PMID: 29669813 Free PMC article.
Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function.
Salyer LG, Salhi HE, Brundage EA, Shettigar V, Sturgill SL, Zanella H, Templeton B, Abay E, Emmer KM, Lowe J, Rafael-Fortney JA, Parinandi N, Foster DB, McKinsey TA, Woulfe KC, Ziolo MT, Biesiadecki BJ. Salyer LG, et al. Among authors: salhi he. Circ Res. 2024 Jan 5;134(1):33-45. doi: 10.1161/CIRCRESAHA.123.323132. Epub 2023 Dec 14. Circ Res. 2024. PMID: 38095088 Free article.