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Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function.
Román-Fernández A, Mansour MA, Kugeratski FG, Anand J, Sandilands E, Galbraith L, Rakovic K, Freckmann EC, Cumming EM, Park J, Nikolatou K, Lilla S, Shaw R, Strachan D, Mason S, Patel R, McGarry L, Katoch A, Campbell KJ, Nixon C, Miller CJ, Leung HY, Le Quesne J, Norman JC, Zanivan S, Blyth K, Bryant DM. Román-Fernández A, et al. Among authors: leung hy. Sci Adv. 2023 Feb 3;9(5):eabq1858. doi: 10.1126/sciadv.abq1858. Epub 2023 Feb 3. Sci Adv. 2023. PMID: 36735782 Free PMC article.
HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer.
Ahmad I, Patel R, Singh LB, Nixon C, Seywright M, Barnetson RJ, Brunton VG, Muller WJ, Edwards J, Sansom OJ, Leung HY. Ahmad I, et al. Among authors: leung hy. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16392-7. doi: 10.1073/pnas.1101263108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930937 Free PMC article.
Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression.
Patel R, Gao M, Ahmad I, Fleming J, Singh LB, Rai TS, McKie AB, Seywright M, Barnetson RJ, Edwards J, Sansom OJ, Leung HY. Patel R, et al. Among authors: leung hy. J Clin Invest. 2013 Mar;123(3):1157-75. doi: 10.1172/JCI63672. Epub 2013 Feb 22. J Clin Invest. 2013. PMID: 23434594 Free PMC article.
Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes.
Li A, Morton JP, Ma Y, Karim SA, Zhou Y, Faller WJ, Woodham EF, Morris HT, Stevenson RP, Juin A, Jamieson NB, MacKay CJ, Carter CR, Leung HY, Yamashiro S, Blyth K, Sansom OJ, Machesky LM. Li A, et al. Among authors: leung hy. Gastroenterology. 2014 May;146(5):1386-96.e1-17. doi: 10.1053/j.gastro.2014.01.046. Epub 2014 Jan 23. Gastroenterology. 2014. PMID: 24462734 Free PMC article.
258 results