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SOS2 modulates the threshold of EGFR signaling to regulate osimertinib efficacy and resistance in lung adenocarcinoma.
Mol Oncol. 2024 Mar;18(3):641-661. doi: 10.1002/1878-0261.13564. Epub 2024 Jan 18.
Mol Oncol. 2024.
PMID: 38073064
Free PMC article.
SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis.
Theard PL, Linke AJ, Sealover NE, Daley BR, Yang J, Cox K, Kortum RL.
Theard PL, et al.
bioRxiv [Preprint]. 2023 Jun 29:2023.01.20.524989. doi: 10.1101/2023.01.20.524989.
bioRxiv. 2023.
PMID: 37425733
Free PMC article.
Updated.
Preprint.
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In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies.
Sealover NE, Theard PL, Hughes JM, Linke AJ, Daley BR, Kortum RL.
Sealover NE, et al. Among authors: theard pl.
bioRxiv [Preprint]. 2023 Jun 28:2023.01.27.525958. doi: 10.1101/2023.01.27.525958.
bioRxiv. 2023.
PMID: 36747633
Free PMC article.
Updated.
Preprint.
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Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer.
Theard PL, Sheffels E, Sealover NE, Linke AJ, Pratico DJ, Kortum RL.
Theard PL, et al.
Elife. 2020 Sep 8;9:e58204. doi: 10.7554/eLife.58204.
Elife. 2020.
PMID: 32897190
Free PMC article.
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Anchorage-independent growth conditions reveal a differential SOS2 dependence for transformation and survival in RAS-mutant cancer cells.
Sheffels E, Sealover NE, Theard PL, Kortum RL.
Sheffels E, et al. Among authors: theard pl.
Small GTPases. 2021 Jan;12(1):67-78. doi: 10.1080/21541248.2019.1611168. Epub 2019 May 7.
Small GTPases. 2021.
PMID: 31062644
Free PMC article.
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