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Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.
Yuan Y, Li H, Sreeram K, Malankhanova T, Boddu R, Strader S, Chang A, Bryant N, Yacoubian TA, Standaert DG, Erb M, Moore DJ, Sanders LH, Lutz MW, Velmeshev D, West AB. Yuan Y, et al. Among authors: sanders lh. bioRxiv [Preprint]. 2024 Apr 17:2024.04.15.589570. doi: 10.1101/2024.04.15.589570. bioRxiv. 2024. PMID: 38659797 Free PMC article. Preprint.
G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage.
Pena N, Richbourg T, Gonzalez-Hunt CP, Qi R, Wren P, Barlow C, Shanks NF, Carlisle HJ, Sanders LH. Pena N, et al. Among authors: sanders lh. NPJ Parkinsons Dis. 2024 Mar 1;10(1):49. doi: 10.1038/s41531-024-00660-y. NPJ Parkinsons Dis. 2024. PMID: 38429321 Free PMC article.
A blood-based marker of mitochondrial DNA damage in Parkinson's disease.
Qi R, Sammler E, Gonzalez-Hunt CP, Barraza I, Pena N, Rouanet JP, Naaldijk Y, Goodson S, Fuzzati M, Blandini F, Erickson KI, Weinstein AM, Lutz MW, Kwok JB, Halliday GM, Dzamko N, Padmanabhan S, Alcalay RN, Waters C, Hogarth P, Simuni T, Smith D, Marras C, Tonelli F, Alessi DR, West AB, Shiva S, Hilfiker S, Sanders LH. Qi R, et al. Among authors: sanders lh. Sci Transl Med. 2023 Aug 30;15(711):eabo1557. doi: 10.1126/scitranslmed.abo1557. Epub 2023 Aug 30. Sci Transl Med. 2023. PMID: 37647388 Free PMC article.
α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans.
Miner KM, Jamenis AS, Bhatia TN, Clark RN, Rajasundaram D, Sauvaigo S, Mason DM, Posimo JM, Abraham N, DeMarco BA, Hu X, Stetler RA, Chen J, Sanders LH, Luk KC, Leak RK. Miner KM, et al. Among authors: sanders lh. Prog Neurobiol. 2022 Sep;216:102307. doi: 10.1016/j.pneurobio.2022.102307. Epub 2022 Jun 13. Prog Neurobiol. 2022. PMID: 35710046 Free PMC article.
Peripheral Klotho and Parkinson's Disease.
Kakar RS, Pastor JV, Moe OW, Ambrosio F, Castaldi D, Sanders LH. Kakar RS, et al. Among authors: sanders lh. Mov Disord. 2021 May;36(5):1274-1276. doi: 10.1002/mds.28530. Epub 2021 Feb 25. Mov Disord. 2021. PMID: 33629770 Free PMC article. No abstract available.
62 results