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Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.
Br J Pharmacol. 2023 Aug;180(15):1965-1980. doi: 10.1111/bph.16055. Epub 2023 Mar 8.
Br J Pharmacol. 2023.
PMID: 36780899
Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice.
Snider B, Geiser A, Yu XP, Beebe EC, Willency JA, Qing K, Guo L, Lu J, Wang X, Yang Q, Efanov A, Adams AC, Coskun T, Emmerson PJ, Alsina-Fernandez J, Ai M.
Snider B, et al. Among authors: beebe ec.
J Endocr Soc. 2019 May 16;3(7):1423-1444. doi: 10.1210/js.2019-00004. eCollection 2019 Jul 1.
J Endocr Soc. 2019.
PMID: 31286109
Free PMC article.
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The novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide transiently delays gastric emptying similarly to selective long-acting GLP-1 receptor agonists.
Urva S, Coskun T, Loghin C, Cui X, Beebe E, O'Farrell L, Briere DA, Benson C, Nauck MA, Haupt A.
Urva S, et al.
Diabetes Obes Metab. 2020 Oct;22(10):1886-1891. doi: 10.1111/dom.14110. Epub 2020 Jul 13.
Diabetes Obes Metab. 2020.
PMID: 32519795
Free PMC article.
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The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling.
Worth AA, Shoop R, Tye K, Feetham CH, D'Agostino G, Dodd GT, Reimann F, Gribble FM, Beebe EC, Dunbar JD, Alexander-Chacko JT, Sindelar DK, Coskun T, Emmerson PJ, Luckman SM.
Worth AA, et al. Among authors: beebe ec.
Elife. 2020 Jul 29;9:e55164. doi: 10.7554/eLife.55164.
Elife. 2020.
PMID: 32723474
Free PMC article.
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