Siegel R - Search Results

1

Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.

Verdino P, Lee SL, Cooper FN, Cottle SR, Grealish PF, Hu CC, Meyer CM, Lin J, Copeland V, Porter G, Schroeder RL, Thompson TD, Porras LL, Dey A, Zhang HY, Beebe EC, Matkovich SJ, Coskun T, Balciunas AM, Ferrante A, Siegel R, Malherbe L, Bivi N, Paavola CD, Hansen RJ, Abernathy MM, Nwosu SO, Carr MC, Heuer JG, Wang X. Verdino P, et al. Among authors: siegel r. Br J Pharmacol. 2023 Aug;180(15):1965-1980. doi: 10.1111/bph.16055. Epub 2023 Mar 8. Br J Pharmacol. 2023. PMID: 36780899

2

Assessment and Clinical Relevance of Serum IL-19 Levels in Psoriasis and Atopic Dermatitis Using a Sensitive and Specific Novel Immunoassay.

Konrad RJ, Higgs RE, Rodgers GH, Ming W, Qian YW, Bivi N, Mack JK, Siegel RW, Nickoloff BJ. Konrad RJ, et al. Sci Rep. 2019 Mar 26;9(1):5211. doi: 10.1038/s41598-019-41609-z. Sci Rep. 2019. PMID: 30914699 Free PMC article. Clinical Trial.

3

Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk.

Bivi N, Moore T, Rodgers G, Denning H, Shockley T, Swearingen CA, Gelfanova V, Calderon B, Peterson DA, Hodsdon ME, Siegel RW, Higgs RE, Konrad RJ. Bivi N, et al. MAbs. 2019 Jul;11(5):861-869. doi: 10.1080/19420862.2019.1612699. Epub 2019 May 17. MAbs. 2019. PMID: 31099718 Free PMC article.

4

Development of a FRET-Based Assay for Analysis of mAbs Internalization and Processing by Dendritic Cells in Preclinical Immunogenicity Risk Assessment.

Wen Y, Cahya S, Zeng W, Lin J, Wang X, Liu L, Malherbe L, Siegel R, Ferrante A, Kaliyaperumal A. Wen Y, et al. Among authors: siegel r. AAPS J. 2020 Apr 16;22(3):68. doi: 10.1208/s12248-020-00444-1. AAPS J. 2020. PMID: 32300899

5

Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms.

Walsh RE, Lannan M, Wen Y, Wang X, Moreland CA, Willency J, Knierman MD, Spindler L, Liu L, Zeng W, Rocha GV, Obungu V, Lu J, Kaliyaperumal A, Ferrante A, Siegel R, Malherbe LP. Walsh RE, et al. Among authors: siegel r. MAbs. 2020 Jan-Dec;12(1):1764829. doi: 10.1080/19420862.2020.1764829. MAbs. 2020. PMID: 32370596 Free PMC article.

6

Development and validation of a novel immunogenicity assay to detect anti-drug and anti-PEG antibodies simultaneously with high sensitivity.

Bivi N, Swearingen CA, Shockley TE, Sloan JH, Pottanat TG, Carter QL, Hodsdon ME, Siegel RW, Konrad RJ. Bivi N, et al. J Immunol Methods. 2020 Nov;486:112856. doi: 10.1016/j.jim.2020.112856. Epub 2020 Sep 9. J Immunol Methods. 2020. PMID: 32916164

7

The HLA class-II immunopeptidomes of AAV capsids proteins.

Brito-Sierra CA, Lannan MB, Siegel RW, Malherbe LP. Brito-Sierra CA, et al. Front Immunol. 2022 Dec 20;13:1067399. doi: 10.3389/fimmu.2022.1067399. eCollection 2022. Front Immunol. 2022. PMID: 36605211 Free PMC article.

8

A Monovalent Fab Affinity-Capture and Elution Bridging Immunoassay Overcomes Rheumatoid Factor Interference while Accurately Detecting Antidrug Antibodies.

Calderon B, Reynolds NA, Swearingen CA, Carter QL, Bivi N, Cramer JW, Alexander CL, Siegel RW, Konrad RJ. Calderon B, et al. J Appl Lab Med. 2023 Sep 7;8(5):896-908. doi: 10.1093/jalm/jfad035. J Appl Lab Med. 2023. PMID: 37473444

9

The HLA class I immunopeptidomes of AAV capsid proteins.

Brito-Sierra CA, Lannan MB, Malherbe LP, Siegel RW. Brito-Sierra CA, et al. Front Immunol. 2023 Aug 16;14:1212136. doi: 10.3389/fimmu.2023.1212136. eCollection 2023. Front Immunol. 2023. PMID: 37662941 Free PMC article.

10

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

Emmerson PJ, Wang F, Du Y, Liu Q, Pickard RT, Gonciarz MD, Coskun T, Hamang MJ, Sindelar DK, Ballman KK, Foltz LA, Muppidi A, Alsina-Fernandez J, Barnard GC, Tang JX, Liu X, Mao X, Siegel R, Sloan JH, Mitchell PJ, Zhang BB, Gimeno RE, Shan B, Wu X. Emmerson PJ, et al. Among authors: siegel r. Nat Med. 2017 Oct;23(10):1215-1219. doi: 10.1038/nm.4393. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846098

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