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Development of a long-acting relaxin analogue, LY3540378, for treatment of chronic heart failure.
Verdino P, Lee SL, Cooper FN, Cottle SR, Grealish PF, Hu CC, Meyer CM, Lin J, Copeland V, Porter G, Schroeder RL, Thompson TD, Porras LL, Dey A, Zhang HY, Beebe EC, Matkovich SJ, Coskun T, Balciunas AM, Ferrante A, Siegel R, Malherbe L, Bivi N, Paavola CD, Hansen RJ, Abernathy MM, Nwosu SO, Carr MC, Heuer JG, Wang X. Verdino P, et al. Br J Pharmacol. 2023 Aug;180(15):1965-1980. doi: 10.1111/bph.16055. Epub 2023 Mar 8. Br J Pharmacol. 2023. PMID: 36780899
Volenrelaxin (LY3540378) increases Renal Plasma Flow: A Randomized Phase 1 Trial.
Tham LS, Heerspink HJL, Wang X, Verdino P, Saifan CG, Benson EA, Goldsmith P, Wang Z, Testani JM, Haupt A, Sam F, Cherney DZI. Tham LS, et al. Among authors: verdino p. Nephrol Dial Transplant. 2024 May 23:gfae112. doi: 10.1093/ndt/gfae112. Online ahead of print. Nephrol Dial Transplant. 2024. PMID: 38782726
Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies.
Bowers PM, Verdino P, Wang Z, da Silva Correia J, Chhoa M, Macondray G, Do M, Neben TY, Horlick RA, Stanfield RL, Wilson IA, King DJ. Bowers PM, et al. Among authors: verdino p. J Biol Chem. 2014 Nov 28;289(48):33557-67. doi: 10.1074/jbc.M114.607176. Epub 2014 Oct 15. J Biol Chem. 2014. PMID: 25320089 Free PMC article.
Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.
Jiménez-Dalmaroni MJ, Radcliffe CM, Harvey DJ, Wormald MR, Verdino P, Ainge GD, Larsen DS, Painter GF, Ulevitch R, Beutler B, Rudd PM, Dwek RA, Wilson IA. Jiménez-Dalmaroni MJ, et al. Among authors: verdino p. Innate Immun. 2015 Feb;21(2):175-93. doi: 10.1177/1753425914524077. Epub 2014 Mar 3. Innate Immun. 2015. PMID: 24591200 Free PMC article.
Mammalian cell display for the discovery and optimization of antibody therapeutics.
Bowers PM, Horlick RA, Kehry MR, Neben TY, Tomlinson GL, Altobell L, Zhang X, Macomber JL, Krapf IP, Wu BF, McConnell AD, Chau B, Berkebile AD, Hare E, Verdino P, King DJ. Bowers PM, et al. Among authors: verdino p. Methods. 2014 Jan 1;65(1):44-56. doi: 10.1016/j.ymeth.2013.06.010. Epub 2013 Jun 20. Methods. 2014. PMID: 23792919
Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation.
Bowers PM, Neben TY, Tomlinson GL, Dalton JL, Altobell L, Zhang X, Macomber JL, Wu BF, Toobian RM, McConnell AD, Verdino P, Chau B, Horlick RA, King DJ. Bowers PM, et al. Among authors: verdino p. J Biol Chem. 2013 Mar 15;288(11):7688-7696. doi: 10.1074/jbc.M112.445502. Epub 2013 Jan 25. J Biol Chem. 2013. PMID: 23355464 Free PMC article.
48 results