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Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion.
Hawkes G, Beaumont RN, Tyrrell J, Power GM, Wood A, Laakso M, Silva LF, Boehnke M, Yin X, Richardson TG, Smith GD, Frayling TM. Hawkes G, et al. Among authors: silva lf. medRxiv [Preprint]. 2023 Feb 7:2023.02.03.23285420. doi: 10.1101/2023.02.03.23285420. medRxiv. 2023. PMID: 36798216 Free PMC article. Updated. Preprint.
Metabolome-wide Mendelian randomization characterizes heterogeneous and shared causal effects of metabolites on human health.
Yin X, Li J, Bose D, Okamoto J, Kwon A, Jackson AU, Silva LF, Oravilahti A, Stringham HM, Ripatti S, Daly M, Palotie A, Scott LJ, Burant CF, Fauman EB, Wen X, Boehnke M, Laakso M, Morrison J. Yin X, et al. Among authors: silva lf. medRxiv [Preprint]. 2023 Jun 29:2023.06.26.23291721. doi: 10.1101/2023.06.26.23291721. medRxiv. 2023. PMID: 37425837 Free PMC article. Preprint.
Adipose tissue eQTL meta-analysis reveals the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits.
Brotman SM, El-Sayed Moustafa JS, Guan L, Broadaway KA, Wang D, Jackson AU, Welch R, Currin KW, Tomlinson M, Vadlamudi S, Stringham HM, Roberts AL, Lakka TA, Oravilahti A, Silva LF, Narisu N, Erdos MR, Yan T, Bonnycastle LL, Raulerson CK, Raza Y, Yan X, Parker SCJ, Kuusisto J, Pajukanta P, Tuomilehto J, Collins FS, Boehnke M, Love MI, Koistinen HA, Laakso M, Mohlke KL, Small KS, Scott LJ. Brotman SM, et al. Among authors: silva lf. bioRxiv [Preprint]. 2023 Oct 27:2023.10.26.563798. doi: 10.1101/2023.10.26.563798. bioRxiv. 2023. PMID: 37961277 Free PMC article. Preprint.
814 results