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Stable Isotope Labeling Reveals Novel Insights Into Ubiquitin-Mediated Protein Aggregation With Age, Calorie Restriction, and Rapamycin Treatment.
Basisty NB, Liu Y, Reynolds J, Karunadharma PP, Dai DF, Fredrickson J, Beyer RP, MacCoss MJ, Rabinovitch PS. Basisty NB, et al. Among authors: fredrickson j. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):561-570. doi: 10.1093/gerona/glx047. J Gerontol A Biol Sci Med Sci. 2018. PMID: 28958078 Free PMC article.
Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment.
Quarles E, Basisty N, Chiao YA, Merrihew G, Gu H, Sweetwyne MT, Fredrickson J, Nguyen NH, Razumova M, Kooiker K, Moussavi-Harami F, Regnier M, Quarles C, MacCoss M, Rabinovitch PS. Quarles E, et al. Among authors: fredrickson j. Aging Cell. 2020 Feb;19(2):e13086. doi: 10.1111/acel.13086. Epub 2019 Dec 10. Aging Cell. 2020. PMID: 31823466 Free PMC article.
A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA.
Sanchez-Contreras M, Sweetwyne MT, Kohrn BF, Tsantilas KA, Hipp MJ, Schmidt EK, Fredrickson J, Whitson JA, Campbell MD, Rabinovitch PS, Marcinek DJ, Kennedy SR. Sanchez-Contreras M, et al. Among authors: fredrickson j. Nucleic Acids Res. 2021 Nov 8;49(19):11103-11118. doi: 10.1093/nar/gkab901. Nucleic Acids Res. 2021. PMID: 34614167 Free PMC article.
Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment.
Whitson JA, Johnson R, Wang L, Bammler TK, Imai SI, Zhang H, Fredrickson J, Latorre-Esteves E, Bitto A, MacCoss MJ, Rabinovitch PS. Whitson JA, et al. Among authors: fredrickson j. Geroscience. 2022 Jun;44(3):1621-1639. doi: 10.1007/s11357-022-00564-w. Epub 2022 Apr 13. Geroscience. 2022. PMID: 35416576 Free PMC article.
Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.
Ghezelayagh TS, Kohrn BF, Fredrickson J, Manhardt E, Radke MR, Katz R, Gray HJ, Urban RR, Pennington KP, Liao JB, Doll KM, Simons EJ, Burzawa JK, Goff BA, Speiser P, Swisher EM, Norquist BM, Risques RA. Ghezelayagh TS, et al. Among authors: fredrickson j. Cancer Res Commun. 2022 Oct;2(10):1282-1292. doi: 10.1158/2767-9764.crc-22-0314. Epub 2022 Oct 27. Cancer Res Commun. 2022. PMID: 36311816 Free PMC article.
Characterization of TP53 mutations in Pap test DNA of women with and without serous ovarian carcinoma.
Krimmel-Morrison JD, Ghezelayagh TS, Lian S, Zhang Y, Fredrickson J, Nachmanson D, Baker KT, Radke MR, Hun E, Norquist BM, Emond MJ, Swisher EM, Risques RA. Krimmel-Morrison JD, et al. Among authors: fredrickson j. Gynecol Oncol. 2020 Feb;156(2):407-414. doi: 10.1016/j.ygyno.2019.11.124. Epub 2019 Dec 12. Gynecol Oncol. 2020. PMID: 31839337 Free PMC article.
Ultra-deep mutational landscape in chronic lymphocytic leukemia uncovers dynamics of resistance to targeted therapies.
Woolston DW, Lee ND, Shadman M, Latorre-Esteves E, Tee XR, Fredrickson J, Kohrn BF, Ujjani C, Eckel A, Till B, Fang M, Radich J, Bozic I, Risques RA, Yeung CCS. Woolston DW, et al. Among authors: fredrickson j. Haematologica. 2024 Mar 1;109(3):835-845. doi: 10.3324/haematol.2023.283372. Haematologica. 2024. PMID: 37706363 Free PMC article.
412 results