Brown JI - Search Results

1

Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.

Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, Lopez McDonald M, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG. Brown JI, et al. Metabolites. 2023 Jan 19;13(2):151. doi: 10.3390/metabo13020151. Metabolites. 2023. PMID: 36837770 Free PMC article.

2

The application of differential scanning fluorimetry in exploring bisubstrate binding to protein arginine N-methyltransferase 1.

Brown JI, Page BDG, Frankel A. Brown JI, et al. Methods. 2020 Mar 15;175:10-23. doi: 10.1016/j.ymeth.2019.11.004. Epub 2019 Nov 11. Methods. 2020. PMID: 31726226

3

The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.

Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA. Heppler LN, et al. Among authors: brown ji. J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23. J Biol Chem. 2022. PMID: 34953855 Free PMC article.

4

Chemically engineering the drug release rate of a PEG-paclitaxel conjugate using click and steric hindrance chemistries for optimal efficacy.

Nguyen A, Chao PH, Ong CY, Rouhollahi E, Fayez NA, Lin L, Brown JI, Böttger R, Page B, Wong H, Li SD. Nguyen A, et al. Among authors: brown ji. Biomaterials. 2022 Oct;289:121735. doi: 10.1016/j.biomaterials.2022.121735. Epub 2022 Aug 13. Biomaterials. 2022. PMID: 36055815

5

Investigating the anti-cancer potential of pyrimethamine analogues through a modern chemical biology lens.

Brown JI, Persaud R, Iliev P, Karmacharya U, Attarha S, Sahile H, Olsen JE, Hanke D, Idowu T, Frank DA, Frankel A, Williams KC, Page BDG. Brown JI, et al. Eur J Med Chem. 2024 Jan 15;264:115971. doi: 10.1016/j.ejmech.2023.115971. Epub 2023 Nov 29. Eur J Med Chem. 2024. PMID: 38071795

6

Methylarginine efflux in nutrient-deprived yeast mitigates disruption of nitric oxide synthesis.

Brown JI, Alibhai J, Zhu E, Frankel A. Brown JI, et al. Amino Acids. 2023 Feb;55(2):215-233. doi: 10.1007/s00726-022-03220-x. Epub 2022 Dec 1. Amino Acids. 2023. PMID: 36454288

7

Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism.

Brown JI, Koopmans T, van Strien J, Martin NI, Frankel A. Brown JI, et al. Chembiochem. 2018 Jan 4;19(1):85-99. doi: 10.1002/cbic.201700521. Epub 2017 Nov 29. Chembiochem. 2018. PMID: 29112789

8

Evaluation of kinetic data: What the numbers tell us about PRMTs.

Frankel A, Brown JI. Frankel A, et al. Among authors: brown ji. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):306-316. doi: 10.1016/j.bbapap.2018.10.010. Epub 2018 Oct 17. Biochim Biophys Acta Proteins Proteom. 2019. PMID: 30342239 Review.

9

Protein arginine methyltransferase 8 modulates mitochondrial bioenergetics and neuroinflammation after hypoxic stress.

Couto E Silva A, Wu CY, Clemons GA, Acosta CH, Chen CT, Possoit HE, Citadin CT, Lee RH, Brown JI, Frankel A, Lin HW. Couto E Silva A, et al. Among authors: brown ji. J Neurochem. 2021 Nov;159(4):742-761. doi: 10.1111/jnc.15462. Epub 2021 Aug 25. J Neurochem. 2021. PMID: 34216036 Free PMC article.

10

Determining evolutionary origin and phylogenetic relationships of mallard-like ducks of Oceania, greater Indonesia, and the Philippines with ddRAD-seq data.

Kaminski M, Brown JI, Seibert SR, Hernández F, Duya MV, Fontanilla IKC, Roshier D, Miles A, Joseph L, Peters JL, Lavretsky P. Kaminski M, et al. Among authors: brown ji. Mol Phylogenet Evol. 2024 Apr 28;197:108085. doi: 10.1016/j.ympev.2024.108085. Online ahead of print. Mol Phylogenet Evol. 2024. PMID: 38688441

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