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Cycloguanil and Analogues Potently Target DHFR in Cancer Cells to Elicit Anti-Cancer Activity.
Brown JI, Wang P, Wong AYL, Petrova B, Persaud R, Soukhtehzari S, Lopez McDonald M, Hanke D, Christensen J, Iliev P, Wang W, Everton DK, Williams KC, Frank DA, Kanarek N, Page BDG. Brown JI, et al. Among authors: wang w, wang p. Metabolites. 2023 Jan 19;13(2):151. doi: 10.3390/metabo13020151. Metabolites. 2023. PMID: 36837770 Free PMC article.
The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA. Heppler LN, et al. Among authors: wang p. J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23. J Biol Chem. 2022. PMID: 34953855 Free PMC article.
Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.
Michaelides IN, Collie GW, Börjesson U, Vasalou C, Alkhatib O, Barlind L, Cheung T, Dale IL, Embrey KJ, Hennessy EJ, Khurana P, Koh CM, Lamb ML, Liu J, Moss TA, O'Neill DJ, Phillips C, Shaw J, Snijder A, Storer RI, Stubbs CJ, Han F, Li C, Qiao J, Sun DQ, Wang J, Wang P, Yang W. Michaelides IN, et al. Among authors: wang j, wang p. J Med Chem. 2023 Jul 13;66(13):8782-8807. doi: 10.1021/acs.jmedchem.3c00401. Epub 2023 Jun 21. J Med Chem. 2023. PMID: 37343272 Free PMC article.
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