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Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression.
Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, Collman RG, Apetrei C, Pandrea I, Else J, Munch J, Kirchhoff F, Davenport MP, Brenchley JM, Silvestri G. Paiardini M, et al. Among authors: ortiz am. Nat Med. 2011 Jun 26;17(7):830-6. doi: 10.1038/nm.2395. Nat Med. 2011. PMID: 21706028 Free PMC article.
Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.
Ortiz AM, Klatt NR, Li B, Yi Y, Tabb B, Hao XP, Sternberg L, Lawson B, Carnathan PM, Cramer EM, Engram JC, Little DM, Ryzhova E, Gonzalez-Scarano F, Paiardini M, Ansari AA, Ratcliffe S, Else JG, Brenchley JM, Collman RG, Estes JD, Derdeyn CA, Silvestri G. Ortiz AM, et al. J Clin Invest. 2011 Nov;121(11):4433-45. doi: 10.1172/JCI46023. Epub 2011 Oct 17. J Clin Invest. 2011. PMID: 22005304 Free PMC article.
Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection.
Klatt NR, Estes JD, Sun X, Ortiz AM, Barber JS, Harris LD, Cervasi B, Yokomizo LK, Pan L, Vinton CL, Tabb B, Canary LA, Dang Q, Hirsch VM, Alter G, Belkaid Y, Lifson JD, Silvestri G, Milner JD, Paiardini M, Haddad EK, Brenchley JM. Klatt NR, et al. Among authors: ortiz am. Mucosal Immunol. 2012 Nov;5(6):646-57. doi: 10.1038/mi.2012.38. Epub 2012 May 30. Mucosal Immunol. 2012. PMID: 22643849 Free PMC article.
Homeostatic cytokines induce CD4 downregulation in African green monkeys independently of antigen exposure to generate simian immunodeficiency virus-resistant CD8αα T cells.
Perkins MR, Briant JA, Calantone N, Whitted S, Vinton CL, Klatt NR, Ourmanov I, Ortiz AM, Hirsch VM, Brenchley JM. Perkins MR, et al. Among authors: ortiz am. J Virol. 2014 Sep;88(18):10714-24. doi: 10.1128/JVI.01331-14. Epub 2014 Jul 2. J Virol. 2014. PMID: 24991011 Free PMC article.
Dysbiotic bacteria translocate in progressive SIV infection.
Klase Z, Ortiz A, Deleage C, Mudd JC, Quiñones M, Schwartzman E, Klatt NR, Canary L, Estes JD, Brenchley JM. Klase Z, et al. Mucosal Immunol. 2015 Sep;8(5):1009-20. doi: 10.1038/mi.2014.128. Epub 2015 Jan 14. Mucosal Immunol. 2015. PMID: 25586559 Free PMC article.
IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques.
Ortiz AM, Klase ZA, DiNapoli SR, Vujkovic-Cvijin I, Carmack K, Perkins MR, Calantone N, Vinton CL, Riddick NE, Gallagher J, Klatt NR, McCune JM, Estes JD, Paiardini M, Brenchley JM. Ortiz AM, et al. Mucosal Immunol. 2016 Mar;9(2):458-67. doi: 10.1038/mi.2015.75. Epub 2015 Aug 19. Mucosal Immunol. 2016. PMID: 26286233 Free PMC article.
Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity.
Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y. Fonseca DM, et al. Among authors: ortiz am. Cell. 2015 Oct 8;163(2):354-66. doi: 10.1016/j.cell.2015.08.030. Cell. 2015. PMID: 26451485 Free PMC article.
234 results