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Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage.
Li T, Ge C, Krämer A, Sareila O, Leu Agelii M, Johansson L, Forslind K, Lönnblom E, Yang M, Xu B, Li Q, Cheng L, Bergström G, Fernandez G, Kastbom A, Rantapää-Dahlqvist S, Gjertsson I, Holmdahl R. Li T, et al. Among authors: li q. Ann Rheum Dis. 2023 Jun;82(6):799-808. doi: 10.1136/ard-2022-223633. Epub 2023 Mar 1. Ann Rheum Dis. 2023. PMID: 36858822
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis.
He Y, Ge C, Moreno-Giró À, Xu B, Beusch CM, Sandor K, Su J, Cheng L, Lönnblom E, Lundqvist C, Slot LM, Tong D, Urbonaviciute V, Liang B, Li T, Lahore GF, Aoun M, Malmström V, Rispens T, Ernfors P, Svensson CI, Scherer HU, Toes REM, Gjertsson I, Ekwall O, Zubarev RA, Holmdahl R. He Y, et al. Among authors: li t. Nat Commun. 2023 Feb 8;14(1):691. doi: 10.1038/s41467-023-36257-x. Nat Commun. 2023. PMID: 36754962 Free PMC article.
Therapy targeting antigen-specific T cells by a peptide-based tolerizing vaccine against autoimmune arthritis.
Urbonaviciute V, Romero-Castillo L, Xu B, Luo H, Schneider N, Weisse S, Do NN, Oliveira-Coelho A, Fernandez Lahore G, Li T, Sabatier P, Beusch CM, Viljanen J, Zubarev RA, Kihlberg J, Bäcklund J, Burkhardt H, Holmdahl R. Urbonaviciute V, et al. Among authors: li t. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218668120. doi: 10.1073/pnas.2218668120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307481 Free PMC article.
Human MHC Class II and Invariant Chain Knock-in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association.
Romero-Castillo L, Li T, Do NN, Sareila O, Xu B, Hennings V, Xu Z, Svensson C, Oliveira-Coelho A, Sener Z, Urbonaviciute V, Ekwall O, Burkhardt H, Holmdahl R. Romero-Castillo L, et al. Among authors: li t. Adv Sci (Weinh). 2024 Apr 11:e2401513. doi: 10.1002/advs.202401513. Online ahead of print. Adv Sci (Weinh). 2024. PMID: 38602454
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