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Nasal administration of anti-CD3 mAb (Foralumab) downregulates NKG7 and increases TGFB1 and GIMAP7 expression in T cells in subjects with COVID-19.
G Moreira T, Gauthier CD, Murphy L, Lanser TB, Paul A, Matos KTF, Mangani D, Izzy S, Rezende RM, Healy BC, Baecher-Allan CM, Chitnis T, Kuchroo V, Weiner HL. G Moreira T, et al. Among authors: lanser tb. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2220272120. doi: 10.1073/pnas.2220272120. Epub 2023 Mar 7. Proc Natl Acad Sci U S A. 2023. PMID: 36881624 Free PMC article. Clinical Trial.
CSMD1 regulates brain complement activity and circuit development.
Baum ML, Wilton DK, Fox RG, Carey A, Hsu YH, Hu R, Jäntti HJ, Fahey JB, Muthukumar AK, Salla N, Crotty W, Scott-Hewitt N, Bien E, Sabatini DA, Lanser TB, Frouin A, Gergits F, Håvik B, Gialeli C, Nacu E, Lage K, Blom AM, Eggan K, McCarroll SA, Johnson MB, Stevens B. Baum ML, et al. Among authors: lanser tb. Brain Behav Immun. 2024 Mar 27;119:317-332. doi: 10.1016/j.bbi.2024.03.041. Online ahead of print. Brain Behav Immun. 2024. PMID: 38552925 Free article.
Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice.
Cox LM, Tatematsu BK, Guo L, LeServe DS, Mayrink J, Oliveira MG, Donnelly D, Fonseca RC, Lemos L, Lanser TB, Rosa AC, Lopes JR, Schwerdtfeger LA, Ribeiro GFC, Lobo ELC, Moreira TG, Oliveira AG, Weiner HL, Rezende RM. Cox LM, et al. Among authors: lanser tb. Brain Behav Immun. 2024 Mar;117:242-254. doi: 10.1016/j.bbi.2024.01.214. Epub 2024 Jan 26. Brain Behav Immun. 2024. PMID: 38281671
Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease.
Lopes JR, Zhang X, Mayrink J, Tatematsu BK, Guo L, LeServe DS, Abou-El-Hassan H, Rong F, Dalton MJ, Oliveira MG, Lanser TB, Liu L, Butovsky O, Rezende RM, Weiner HL. Lopes JR, et al. Among authors: lanser tb. Proc Natl Acad Sci U S A. 2023 Sep 12;120(37):e2309221120. doi: 10.1073/pnas.2309221120. Epub 2023 Sep 5. Proc Natl Acad Sci U S A. 2023. PMID: 37669383 Free PMC article.