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Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes.
Adamson SE, Meher AK, Chiu YH, Sandilos JK, Oberholtzer NP, Walker NN, Hargett SR, Seaman SA, Peirce-Cottler SM, Isakson BE, McNamara CA, Keller SR, Harris TE, Bayliss DA, Leitinger N. Adamson SE, et al. Among authors: hargett sr. Mol Metab. 2015 Jul 3;4(9):610-8. doi: 10.1016/j.molmet.2015.06.009. eCollection 2015 Sep. Mol Metab. 2015. PMID: 26413467 Free PMC article.
Dietary sugar intake increases liver tumor incidence in female mice.
Healy ME, Lahiri S, Hargett SR, Chow JD, Byrne FL, Breen DS, Kenwood BM, Taddeo EP, Lackner C, Caldwell SH, Hoehn KL. Healy ME, et al. Among authors: hargett sr. Sci Rep. 2016 Feb 29;6:22292. doi: 10.1038/srep22292. Sci Rep. 2016. PMID: 26924712 Free PMC article.
[1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis.
Childress ES, Salamoun JM, Hargett SR, Alexopoulos SJ, Chen SY, Shah DP, Santiago-Rivera J, Garcia CJ, Dai Y, Tucker SP, Hoehn KL, Santos WL. Childress ES, et al. Among authors: hargett sr. J Med Chem. 2020 Mar 12;63(5):2511-2526. doi: 10.1021/acs.jmedchem.9b01440. Epub 2020 Feb 17. J Med Chem. 2020. PMID: 32017849 Free PMC article.
Anilinopyrazines as potential mitochondrial uncouplers.
Murray JH, Hargett S, Hoehn KL, Santos WL. Murray JH, et al. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127057. doi: 10.1016/j.bmcl.2020.127057. Epub 2020 Feb 21. Bioorg Med Chem Lett. 2020. PMID: 32113842
6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis.
Salamoun JM, Garcia CJ, Hargett SR, Murray JH, Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Tucker SP, Hoehn KL, Santos WL. Salamoun JM, et al. Among authors: hargett sr. J Med Chem. 2020 Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. Epub 2020 May 27. J Med Chem. 2020. PMID: 32392051 Free PMC article.
23 results