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MYC determines lineage commitment in KRAS-driven primary liver cancer development.
J Hepatol. 2023 Jul;79(1):141-149. doi: 10.1016/j.jhep.2023.02.039. Epub 2023 Mar 9.
J Hepatol. 2023.
PMID: 36906109
Free article.
Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity.
Dimitrov T, Anli C, Moschopoulou AA, Kronenberger T, Kudolo M, Geibel C, Schwalm MP, Knapp S, Zender L, Forster M, Laufer S.
Dimitrov T, et al. Among authors: moschopoulou aa.
Eur J Med Chem. 2022 May 5;235:114234. doi: 10.1016/j.ejmech.2022.114234. Epub 2022 Mar 8.
Eur J Med Chem. 2022.
PMID: 35325634
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Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
Dimitrov T, Moschopoulou AA, Seidel L, Kronenberger T, Kudolo M, Poso A, Geibel C, Wölffing P, Dauch D, Zender L, Schollmeyer D, Bajorath J, Forster M, Laufer S.
Dimitrov T, et al. Among authors: moschopoulou aa.
J Med Chem. 2023 Jun 8;66(11):7304-7330. doi: 10.1021/acs.jmedchem.2c02104. Epub 2023 May 25.
J Med Chem. 2023.
PMID: 37226670
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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure.
Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L.
Zwirner S, et al. Among authors: moschopoulou aa.
Cell. 2024 Mar 28;187(7):1666-1684.e26. doi: 10.1016/j.cell.2024.02.023. Epub 2024 Mar 14.
Cell. 2024.
PMID: 38490194
Free PMC article.
Clinical Trial.
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