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Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering.
Michels KR, Sheih A, Hernandez SA, Brandes AH, Parrilla D, Irwin B, Perez AM, Ting HA, Nicolai CJ, Gervascio T, Shin S, Pankau MD, Muhonen M, Freeman J, Gould S, Getto R, Larson RP, Ryu BY, Scharenberg AM, Sullivan AM, Green S. Michels KR, et al. Among authors: ryu by. J Immunother Cancer. 2023 Mar;11(3):e006292. doi: 10.1136/jitc-2022-006292. J Immunother Cancer. 2023. PMID: 36918221 Free PMC article.
Tracking genome engineering outcome at individual DNA breakpoints.
Certo MT, Ryu BY, Annis JE, Garibov M, Jarjour J, Rawlings DJ, Scharenberg AM. Certo MT, et al. Among authors: ryu by. Nat Methods. 2011 Jul 10;8(8):671-6. doi: 10.1038/nmeth.1648. Nat Methods. 2011. PMID: 21743461 Free PMC article.
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption.
Certo MT, Gwiazda KS, Kuhar R, Sather B, Curinga G, Mandt T, Brault M, Lambert AR, Baxter SK, Jacoby K, Ryu BY, Kiem HP, Gouble A, Paques F, Rawlings DJ, Scharenberg AM. Certo MT, et al. Among authors: ryu by. Nat Methods. 2012 Oct;9(10):973-5. doi: 10.1038/nmeth.2177. Epub 2012 Sep 2. Nat Methods. 2012. PMID: 22941364 Free PMC article.
Sustained fetal hemoglobin induction in vivo is achieved by BCL11A interference and coexpressed truncated erythropoietin receptor.
Uchida N, Ferrara F, Drysdale CM, Yapundich M, Gamer J, Nassehi T, DiNicola J, Shibata Y, Wielgosz M, Kim YS, Bauler M, Throm RE, Haro-Mora JJ, Demirci S, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Ryu B, Tisdale JF. Uchida N, et al. Sci Transl Med. 2021 Apr 28;13(591):eabb0411. doi: 10.1126/scitranslmed.abb0411. Sci Transl Med. 2021. PMID: 33910976
Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media.
Bauler M, Roberts JK, Wu CC, Fan B, Ferrara F, Yip BH, Diao S, Kim YI, Moore J, Zhou S, Wielgosz MM, Ryu B, Throm RE. Bauler M, et al. Mol Ther Methods Clin Dev. 2019 Nov 26;17:58-68. doi: 10.1016/j.omtm.2019.11.011. eCollection 2020 Jun 12. Mol Ther Methods Clin Dev. 2019. PMID: 31890741 Free PMC article.
123 results