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Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering.
Michels KR, Sheih A, Hernandez SA, Brandes AH, Parrilla D, Irwin B, Perez AM, Ting HA, Nicolai CJ, Gervascio T, Shin S, Pankau MD, Muhonen M, Freeman J, Gould S, Getto R, Larson RP, Ryu BY, Scharenberg AM, Sullivan AM, Green S. Michels KR, et al. Among authors: scharenberg am. J Immunother Cancer. 2023 Mar;11(3):e006292. doi: 10.1136/jitc-2022-006292. J Immunother Cancer. 2023. PMID: 36918221 Free PMC article.
Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.
Schmidt MJ, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, Gamalinda M, Galonska C, Takeuchi R, Wang K, Reiss C, Dehne K, Lukason MJ, Noma A, Park-Windhol C, Allocca M, Kantardzhieva A, Sane S, Kosakowska K, Cafferty B, Tebbe J, Spencer SJ, Munzer S, Cheng CJ, Scaria A, Scharenberg AM, Cohnen A, Coco WM. Schmidt MJ, et al. Among authors: scharenberg am. Nat Commun. 2023 Jun 13;14(1):3503. doi: 10.1038/s41467-023-39141-w. Nat Commun. 2023. PMID: 37311765 Free PMC article. No abstract available.
Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases.
Schmidt MJ, Gupta A, Bednarski C, Gehrig-Giannini S, Richter F, Pitzler C, Gamalinda M, Galonska C, Takeuchi R, Wang K, Reiss C, Dehne K, Lukason MJ, Noma A, Park-Windhol C, Allocca M, Kantardzhieva A, Sane S, Kosakowska K, Cafferty B, Tebbe J, Spencer SJ, Munzer S, Cheng CJ, Scaria A, Scharenberg AM, Cohnen A, Coco WM. Schmidt MJ, et al. Among authors: scharenberg am. Nat Commun. 2021 Jul 9;12(1):4219. doi: 10.1038/s41467-021-24454-5. Nat Commun. 2021. PMID: 34244505 Free PMC article.
Therapeutically relevant engraftment of a CRISPR-Cas9-edited HSC-enriched population with HbF reactivation in nonhuman primates.
Humbert O, Radtke S, Samuelson C, Carrillo RR, Perez AM, Reddy SS, Lux C, Pattabhi S, Schefter LE, Negre O, Lee CM, Bao G, Adair JE, Peterson CW, Rawlings DJ, Scharenberg AM, Kiem HP. Humbert O, et al. Among authors: scharenberg am. Sci Transl Med. 2019 Jul 31;11(503):eaaw3768. doi: 10.1126/scitranslmed.aaw3768. Sci Transl Med. 2019. PMID: 31366580 Free PMC article.
Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.
Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP. Humbert O, et al. Among authors: scharenberg am. Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451. Blood Adv. 2018. PMID: 29720491 Free PMC article.
Therapeutic Gene Editing Safety and Specificity.
Lux CT, Scharenberg AM. Lux CT, et al. Among authors: scharenberg am. Hematol Oncol Clin North Am. 2017 Oct;31(5):787-795. doi: 10.1016/j.hoc.2017.05.002. Epub 2017 Jun 29. Hematol Oncol Clin North Am. 2017. PMID: 28895847 Free PMC article. Review.
116 results