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P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.
Lin KH, Rutter JC, Xie A, Killarney ST, Vaganay C, Benaksas C, Ling F, Sodaro G, Meslin PA, Bassil CF, Fenouille N, Hoj J, Washart R, Ang HX, Cerda-Smith C, Chaintreuil P, Jacquel A, Auberger P, Forget A, Itzykson R, Lu M, Lin J, Pierobon M, Sheng Z, Li X, Chilkoti A, Owzar K, Rizzieri DA, Pardee TS, Benajiba L, Petricoin E, Puissant A, Wood KC. Lin KH, et al. Nat Cancer. 2022 Jul;3(7):837-851. doi: 10.1038/s43018-022-00394-x. Epub 2022 Jun 6. Nat Cancer. 2022. PMID: 35668193 Free PMC article.
ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.
Mayro B, Hoj JP, Cerda-Smith CG, Hutchinson HM, Caminear MW, Thrash HL, Winter PS, Wardell SE, McDonnell DP, Wu C, Wood KC, Pendergast AM. Mayro B, et al. Among authors: hoj jp. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2210418120. doi: 10.1073/pnas.2210418120. Epub 2023 Apr 11. Proc Natl Acad Sci U S A. 2023. PMID: 37040401 Free PMC article.
ABL1 and ABL2 promote medulloblastoma leptomeningeal dissemination.
Jones JK, Zhang H, Lyne AM, Cavalli FMG, Hassen WE, Stevenson K, Kornahrens R, Yang Y, Li S, Dell S, Reitman ZJ, Herndon JE 2nd, Hoj J, Pendergast AM, Thompson EM. Jones JK, et al. Neurooncol Adv. 2023 Aug 7;5(1):vdad095. doi: 10.1093/noajnl/vdad095. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 37781087 Free PMC article.
15 results