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Structural basis of selective cannabinoid CB2 receptor activation.
Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T. Li X, et al. Among authors: wu l. Nat Commun. 2023 Mar 15;14(1):1447. doi: 10.1038/s41467-023-37112-9. Nat Commun. 2023. PMID: 36922494 Free PMC article.
Crystal Structure of the Human Cannabinoid Receptor CB2.
Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Li X, et al. Among authors: wu y, wu m, wu l. Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10. Cell. 2019. PMID: 30639103 Free PMC article.
Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.
Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu ZJ, Müller CE, Stevens RC. Claff T, et al. Among authors: wu l. Sci Adv. 2019 Nov 27;5(11):eaax9115. doi: 10.1126/sciadv.aax9115. eCollection 2019 Nov. Sci Adv. 2019. PMID: 31807708 Free PMC article.
Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures.
Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Brust CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ. Hua T, et al. Among authors: wu y, wu m, wu l. Cell. 2020 Feb 20;180(4):655-665.e18. doi: 10.1016/j.cell.2020.01.008. Epub 2020 Jan 30. Cell. 2020. PMID: 32004463 Free PMC article.
Full-length human GLP-1 receptor structure without orthosteric ligands.
Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC. Wu F, et al. Among authors: wu l. Nat Commun. 2020 Mar 9;11(1):1272. doi: 10.1038/s41467-020-14934-5. Nat Commun. 2020. PMID: 32152292 Free PMC article.
Structural insights into the activation initiation of full-length mGlu1.
Zhang J, Qu L, Wu L, Tang X, Luo F, Xu W, Xu Y, Liu ZJ, Hua T. Zhang J, et al. Among authors: wu l. Protein Cell. 2021 Aug;12(8):662-667. doi: 10.1007/s13238-020-00808-5. Epub 2020 Dec 5. Protein Cell. 2021. PMID: 33278019 Free PMC article. No abstract available.
Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsøe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Bräuner-Osborne H, Gloriam DE, Hua T, Liu ZJ. Zhou Y, et al. Among authors: wu m, wu l. Cell Res. 2022 Feb;32(2):210-213. doi: 10.1038/s41422-021-00591-w. Epub 2021 Dec 17. Cell Res. 2022. PMID: 34916631 Free PMC article. No abstract available.
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