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A rare human variant that disrupts GPR10 signalling causes weight gain in mice.
Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, Arslan M, Yeo GSH, Froguel P, Bechtold DA, Adamson A, Humphreys N, Barroso I, Luckman SM, Farooqi IS. Talbot F, et al. Among authors: yeo gsh. Nat Commun. 2023 Mar 15;14(1):1450. doi: 10.1038/s41467-023-36966-3. Nat Commun. 2023. PMID: 36922513 Free PMC article.
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S. Challis BG, et al. Hum Mol Genet. 2002 Aug 15;11(17):1997-2004. doi: 10.1093/hmg/11.17.1997. Hum Mol Genet. 2002. PMID: 12165561
243 results