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A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder.
Baum AE, Akula N, Cabanero M, Cardona I, Corona W, Klemens B, Schulze TG, Cichon S, Rietschel M, Nöthen MM, Georgi A, Schumacher J, Schwarz M, Abou Jamra R, Höfels S, Propping P, Satagopan J, Detera-Wadleigh SD, Hardy J, McMahon FJ. Baum AE, et al. Among authors: akula n. Mol Psychiatry. 2008 Feb;13(2):197-207. doi: 10.1038/sj.mp.4002012. Epub 2007 May 8. Mol Psychiatry. 2008. PMID: 17486107 Free PMC article.
Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder.
Schulze TG, Detera-Wadleigh SD, Akula N, Gupta A, Kassem L, Steele J, Pearl J, Strohmaier J, Breuer R, Schwarz M, Propping P, Nöthen MM, Cichon S, Schumacher J; NIMH Genetics Initiative Bipolar Disorder Consortium; Rietschel M, McMahon FJ. Schulze TG, et al. Among authors: akula n. Mol Psychiatry. 2009 May;14(5):487-91. doi: 10.1038/mp.2008.134. Epub 2008 Dec 16. Mol Psychiatry. 2009. PMID: 19088739 Free PMC article.
Genetic variation in cholinergic muscarinic-2 receptor gene modulates M2 receptor binding in vivo and accounts for reduced binding in bipolar disorder.
Cannon DM, Klaver JK, Gandhi SK, Solorio G, Peck SA, Erickson K, Akula N, Savitz J, Eckelman WC, Furey ML, Sahakian BJ, McMahon FJ, Drevets WC. Cannon DM, et al. Among authors: akula n. Mol Psychiatry. 2011 Apr;16(4):407-18. doi: 10.1038/mp.2010.24. Epub 2010 Mar 30. Mol Psychiatry. 2011. PMID: 20351719 Free PMC article.
A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study.
Liu X, Cannon DM, Akula N, Moya PR, Knudsen GM, Arentzen TE, Steele J, Laje G, Drevets WC, McMahon FJ. Liu X, et al. Among authors: akula n. Mol Psychiatry. 2011 Jun;16(6):584-5. doi: 10.1038/mp.2011.1. Epub 2011 Feb 22. Mol Psychiatry. 2011. PMID: 21339755 Free PMC article. No abstract available.
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nöthen MM, Rietschel M; BiGS; McMahon FJ, Farmer A, McGuffin P, Craig I, Lewis C, Hosang G, Cohen-Woods S, Vincent JB, Kennedy JL, Strauss J. Chen DT, et al. Among authors: akula n. Mol Psychiatry. 2013 Feb;18(2):195-205. doi: 10.1038/mp.2011.157. Epub 2011 Dec 20. Mol Psychiatry. 2013. PMID: 22182935
Replication and meta-analysis of TMEM132D gene variants in panic disorder.
Erhardt A, Akula N, Schumacher J, Czamara D, Karbalai N, Müller-Myhsok B, Mors O, Borglum A, Kristensen AS, Woldbye DP, Koefoed P, Eriksson E, Maron E, Metspalu A, Nurnberger J, Philibert RA, Kennedy J, Domschke K, Reif A, Deckert J, Otowa T, Kawamura Y, Kaiya H, Okazaki Y, Tanii H, Tokunaga K, Sasaki T, Ioannidis JP, McMahon FJ, Binder EB. Erhardt A, et al. Among authors: akula n. Transl Psychiatry. 2012 Sep 4;2(9):e156. doi: 10.1038/tp.2012.85. Transl Psychiatry. 2012. PMID: 22948381 Free PMC article.
RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder.
Akula N, Barb J, Jiang X, Wendland JR, Choi KH, Sen SK, Hou L, Chen DT, Laje G, Johnson K, Lipska BK, Kleinman JE, Corrada-Bravo H, Detera-Wadleigh S, Munson PJ, McMahon FJ. Akula N, et al. Mol Psychiatry. 2014 Nov;19(11):1179-85. doi: 10.1038/mp.2013.170. Epub 2014 Jan 7. Mol Psychiatry. 2014. PMID: 24393808 Free PMC article.
97 results