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Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
Gallego RA, Bernier L, Chen H, Cho-Schultz S, Chung L, Collins M, Del Bel M, Elleraas J, Costa Jones C, Cronin CN, Edwards M, Fang X, Fisher T, He M, Hoffman J, Huo R, Jalaie M, Johnson E, Johnson TW, Kania RS, Kraus M, Lafontaine J, Le P, Liu T, Maestre M, Matthews J, McTigue M, Miller N, Mu Q, Qin X, Ren S, Richardson P, Rohner A, Sach N, Shao L, Smith G, Su R, Sun B, Timofeevski S, Tran P, Wang S, Wang W, Zhou R, Zhu J, Nair SK. Gallego RA, et al. Among authors: bernier l. J Med Chem. 2023 Apr 13;66(7):4888-4909. doi: 10.1021/acs.jmedchem.2c02038. Epub 2023 Mar 20. J Med Chem. 2023. PMID: 36940470
Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.
Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, Ferre RA, Gajiwala KS, Hemkens M, Kania RS, Kath JC, Matthews J, Murray BW, Niessen S, Orr ST, Pairish M, Sach NW, Shen H, Shi M, Solowiej J, Tran K, Tseng E, Vicini P, Wang Y, Weinrich SL, Zhou R, Zientek M, Liu L, Luo Y, Xin S, Zhang C, Lafontaine J. Planken S, et al. Among authors: bernier l. J Med Chem. 2017 Apr 13;60(7):3002-3019. doi: 10.1021/acs.jmedchem.6b01894. Epub 2017 Mar 29. J Med Chem. 2017. PMID: 28287730
High-Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates.
Clement HA, Boghi M, McDonald RM, Bernier L, Coe JW, Farrell W, Helal CJ, Reese MR, Sach NW, Lee JC, Hall DG. Clement HA, et al. Among authors: bernier l. Angew Chem Int Ed Engl. 2019 Dec 16;58(51):18405-18409. doi: 10.1002/anie.201909308. Epub 2019 Oct 31. Angew Chem Int Ed Engl. 2019. PMID: 31591755
Probing the chemical 'reactome' with high-throughput experimentation data.
King-Smith E, Berritt S, Bernier L, Hou X, Klug-McLeod JL, Mustakis J, Sach NW, Tucker JW, Yang Q, Howard RM, Lee AA. King-Smith E, et al. Among authors: bernier l. Nat Chem. 2024 Apr;16(4):633-643. doi: 10.1038/s41557-023-01393-w. Epub 2024 Jan 2. Nat Chem. 2024. PMID: 38168924 Free PMC article.
Visible-Light-Initiated Manganese Catalysis for C-H Alkylation of Heteroarenes: Applications and Mechanistic Studies.
Nuhant P, Oderinde MS, Genovino J, Juneau A, Gagné Y, Allais C, Chinigo GM, Choi C, Sach NW, Bernier L, Fobian YM, Bundesmann MW, Khunte B, Frenette M, Fadeyi OO. Nuhant P, et al. Among authors: bernier l. Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15309-15313. doi: 10.1002/anie.201707958. Epub 2017 Oct 26. Angew Chem Int Ed Engl. 2017. PMID: 28960645
Examining sexual minority engagement in recovery community centers.
Bernier LB, Foley JD, Salomaa AC, Scheer JR, Kelly J, Hoeppner B, Batchelder AW. Bernier LB, et al. J Subst Use Addict Treat. 2024 Jun;161:209340. doi: 10.1016/j.josat.2024.209340. Epub 2024 Mar 15. J Subst Use Addict Treat. 2024. PMID: 38494052
Gender Differences in Pharmacokinetics: A Perspective on Contrast Agents.
Courchesne M, Manrique G, Bernier L, Moussa L, Cresson J, Gutzeit A, Froehlich JM, Koh DM, Chartrand-Lefebvre C, Matoori S. Courchesne M, et al. Among authors: bernier l. ACS Pharmacol Transl Sci. 2023 Dec 12;7(1):8-17. doi: 10.1021/acsptsci.3c00116. eCollection 2024 Jan 12. ACS Pharmacol Transl Sci. 2023. PMID: 38230293 Review.
192 results