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Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1.
J Med Chem. 2023 Apr 13;66(7):4888-4909. doi: 10.1021/acs.jmedchem.2c02038. Epub 2023 Mar 20.
J Med Chem. 2023.
PMID: 36940470
Lipophilic Efficiency as an Important Metric in Drug Design.
Johnson TW, Gallego RA, Edwards MP.
Johnson TW, et al. Among authors: gallego ra.
J Med Chem. 2018 Aug 9;61(15):6401-6420. doi: 10.1021/acs.jmedchem.8b00077. Epub 2018 Apr 17.
J Med Chem. 2018.
PMID: 29589935
Review.
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Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase.
Johnson TW, Bolanos B, Brooun A, Gallego RA, Gehlhaar D, Jalaie M, McTigue M, Timofeevski S.
Johnson TW, et al. Among authors: gallego ra.
ACS Med Chem Lett. 2018 Aug 24;9(9):872-877. doi: 10.1021/acsmedchemlett.8b00348. eCollection 2018 Sep 13.
ACS Med Chem Lett. 2018.
PMID: 30258533
Free PMC article.
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Reviving B-Factors: Retrospective Normalized B-Factor Analysis of c-ros Oncogene 1 Receptor Tyrosine Kinase and Anaplastic Lymphoma Kinase L1196M with Crizotinib and Lorlatinib.
Johnson TW, Gallego RA, Brooun A, Gehlhaar D, McTigue M.
Johnson TW, et al. Among authors: gallego ra.
ACS Med Chem Lett. 2018 Jun 18;9(9):878-883. doi: 10.1021/acsmedchemlett.8b00147. eCollection 2018 Sep 13.
ACS Med Chem Lett. 2018.
PMID: 30258534
Free PMC article.
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Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation.
Johnson E, McTigue M, Gallego RA, Johnson TW, Timofeevski S, Maestre M, Fisher TS, Kania R, Sawasdikosol S, Burakoff S, Cronin CN.
Johnson E, et al. Among authors: gallego ra.
J Biol Chem. 2019 Jun 7;294(23):9029-9036. doi: 10.1074/jbc.AC119.007466. Epub 2019 Apr 24.
J Biol Chem. 2019.
PMID: 31018963
Free PMC article.
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Randomized phase II trial of FOLFIRI-panitumumab compared with FOLFIRI alone in patients with RAS wild-type circulating tumor DNA metastatic colorectal cancer beyond progression to first-line FOLFOX-panitumumab: the BEYOND study (GEMCAD 17-01).
Aparicio J, Virgili Manrique AC, Capdevila J, Muñoz Boza F, Galván P, Richart P, Oliveres H, Páez D, Hernando J, Serrano S, Vera R, Hernandez-Yagüe X, Gallego RÁ, Riesco-Martinez MC, García de Albeniz X, Maurel J.
Aparicio J, et al. Among authors: gallego ra.
Clin Transl Oncol. 2022 Nov;24(11):2155-2165. doi: 10.1007/s12094-022-02868-x. Epub 2022 Jun 27.
Clin Transl Oncol. 2022.
PMID: 35761123
Free PMC article.
Clinical Trial.
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