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Genomic characterization of DICER1-associated neoplasms uncovers molecular classes.
Kommoss FKF, Chong AS, Chong AL, Pfaff E, Jones DTW, Hiemcke-Jiwa LS, Kester LA, Flucke U, Gessler M, Schrimpf D, Sahm F, Clarke BA, Stewart CJR, Wang Y, Gilks CB, Kommoss F, Huntsman DG, Schüller U, Koelsche C, McCluggage WG, von Deimling A, Foulkes WD. Kommoss FKF, et al. Among authors: wang y. Nat Commun. 2023 Mar 25;14(1):1677. doi: 10.1038/s41467-023-37092-w. Nat Commun. 2023. PMID: 36966138 Free PMC article.
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Wiegand KC, Hennessy BT, Leung S, Wang Y, Ju Z, McGahren M, Kalloger SE, Finlayson S, Stemke-Hale K, Lu Y, Zhang F, Anglesio MS, Gilks B, Mills GB, Huntsman DG, Carey MS. Wiegand KC, et al. Among authors: wang y. BMC Cancer. 2014 Feb 22;14:120. doi: 10.1186/1471-2407-14-120. BMC Cancer. 2014. PMID: 24559118 Free PMC article.
p53 is positively regulated by miR-542-3p.
Wang Y, Huang JW, Castella M, Huntsman DG, Taniguchi T. Wang Y, et al. Cancer Res. 2014 Jun 15;74(12):3218-27. doi: 10.1158/0008-5472.CAN-13-1706. Epub 2014 Apr 24. Cancer Res. 2014. PMID: 24762395 Free PMC article.
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
Karnezis AN, Wang Y, Ramos P, Hendricks WP, Oliva E, D'Angelo E, Prat J, Nucci MR, Nielsen TO, Chow C, Leung S, Kommoss F, Kommoss S, Silva A, Ronnett BM, Rabban JT, Bowtell DD, Weissman BE, Trent JM, Gilks CB, Huntsman DG. Karnezis AN, et al. Among authors: wang y. J Pathol. 2016 Feb;238(3):389-400. doi: 10.1002/path.4633. Epub 2015 Dec 21. J Pathol. 2016. PMID: 26356327 Free PMC article.
ARID1A-mutated ovarian cancers depend on HDAC6 activity.
Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher FJ III, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R. Bitler BG, et al. Among authors: wang y. Nat Cell Biol. 2017 Aug;19(8):962-973. doi: 10.1038/ncb3582. Epub 2017 Jul 24. Nat Cell Biol. 2017. PMID: 28737768 Free PMC article.
DICER1 hot-spot mutations in ovarian gynandroblastoma.
Wang Y, Karnezis AN, Magrill J, Tessier-Cloutier B, Lum A, Senz J, Gilks CB, McCluggage WG, Huntsman DG, Kommoss F. Wang Y, et al. Histopathology. 2018 Aug;73(2):306-313. doi: 10.1111/his.13630. Epub 2018 Jun 5. Histopathology. 2018. PMID: 29660837
Histone Deacetylase Inhibitors Synergize with Catalytic Inhibitors of EZH2 to Exhibit Antitumor Activity in Small Cell Carcinoma of the Ovary, Hypercalcemic Type.
Wang Y, Chen SY, Colborne S, Lambert G, Shin CY, Santos ND, Orlando KA, Lang JD, Hendricks WPD, Bally MB, Karnezis AN, Hass R, Underhill TM, Morin GB, Trent JM, Weissman BE, Huntsman DG. Wang Y, et al. Mol Cancer Ther. 2018 Dec;17(12):2767-2779. doi: 10.1158/1535-7163.MCT-18-0348. Epub 2018 Sep 19. Mol Cancer Ther. 2018. PMID: 30232145 Free PMC article.
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