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Page 1
Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.
Safina BS, McKerrall SJ, Sun S, Chen CA, Chowdhury S, Jia Q, Li J, Zenova AY, Andrez JC, Bankar G, Bergeron P, Chang JH, Chang E, Chen J, Dean R, Decker SM, DiPasquale A, Focken T, Hemeon I, Khakh K, Kim A, Kwan R, Lindgren A, Lin S, Maher J, Mezeyova J, Misner D, Nelkenbrecher K, Pang J, Reese R, Shields SD, Sojo L, Sheng T, Verschoof H, Waldbrook M, Wilson MS, Xie Z, Young C, Zabka TS, Hackos DH, Ortwine DF, White AD, Johnson JP Jr, Robinette CL, Dehnhardt CM, Cohen CJ, Sutherlin DP. Safina BS, et al. Among authors: mckerrall sj. J Med Chem. 2021 Mar 25;64(6):2953-2966. doi: 10.1021/acs.jmedchem.1c00049. Epub 2021 Mar 8. J Med Chem. 2021. PMID: 33682420
Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.
McKerrall SJ, Nguyen T, Lai KW, Bergeron P, Deng L, DiPasquale A, Chang JH, Chen J, Chernov-Rogan T, Hackos DH, Maher J, Ortwine DF, Pang J, Payandeh J, Proctor WR, Shields SD, Vogt J, Ji P, Liu W, Ballini E, Schumann L, Tarozzo G, Bankar G, Chowdhury S, Hasan A, Johnson JP Jr, Khakh K, Lin S, Cohen CJ, Dehnhardt CM, Safina BS, Sutherlin DP. McKerrall SJ, et al. J Med Chem. 2019 Apr 25;62(8):4091-4109. doi: 10.1021/acs.jmedchem.9b00141. Epub 2019 Apr 16. J Med Chem. 2019. PMID: 30943032
Nav1.7 inhibitors for the treatment of chronic pain.
McKerrall SJ, Sutherlin DP. McKerrall SJ, et al. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3141-3149. doi: 10.1016/j.bmcl.2018.08.007. Epub 2018 Aug 12. Bioorg Med Chem Lett. 2018. PMID: 30139550 Review.
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors.
Chernov-Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones SW, Beresini MH, Liu C, Ortwine DF, McKerrall SJ, Hackos DH, Sutherlin D, Cohen CJ, Chen J. Chernov-Rogan T, et al. Among authors: mckerrall sj. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E792-E801. doi: 10.1073/pnas.1713701115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311306 Free PMC article.
Chemical Proteomics Identifies SLC25A20 as a Functional Target of the Ingenol Class of Actinic Keratosis Drugs.
Parker CG, Kuttruff CA, Galmozzi A, Jørgensen L, Yeh CH, Hermanson DJ, Wang Y, Artola M, McKerrall SJ, Josyln CM, Nørremark B, Dünstl G, Felding J, Saez E, Baran PS, Cravatt BF. Parker CG, et al. Among authors: mckerrall sj. ACS Cent Sci. 2017 Dec 27;3(12):1276-1285. doi: 10.1021/acscentsci.7b00420. Epub 2017 Dec 6. ACS Cent Sci. 2017. PMID: 29296668 Free PMC article.
Correction to "Development of a Concise Synthesis of (+)-Ingenol".
McKerrall SJ, Jørgensen L, Kuttruff CA, Ungeheuer F, Baran PS. McKerrall SJ, et al. J Am Chem Soc. 2015 Nov 18;137(45):14545. doi: 10.1021/jacs.5b11112. Epub 2015 Nov 4. J Am Chem Soc. 2015. PMID: 26535919 No abstract available.
Development of a concise synthesis of (+)-ingenol.
McKerrall SJ, Jørgensen L, Kuttruff CA, Ungeheuer F, Baran PS. McKerrall SJ, et al. J Am Chem Soc. 2014 Apr 16;136(15):5799-810. doi: 10.1021/ja501881p. Epub 2014 Apr 8. J Am Chem Soc. 2014. PMID: 24712341
14-step synthesis of (+)-ingenol from (+)-3-carene.
Jørgensen L, McKerrall SJ, Kuttruff CA, Ungeheuer F, Felding J, Baran PS. Jørgensen L, et al. Among authors: mckerrall sj. Science. 2013 Aug 23;341(6148):878-82. doi: 10.1126/science.1241606. Epub 2013 Aug 1. Science. 2013. PMID: 23907534