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Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease.
Vicente-Rodríguez M, Mancuso R, Peris-Yague A, Simmons C; NIMA Consortium; Gómez-Nicola D, Perry VH, Turkheimer F, Lovestone S, Parker CA, Cash D. Vicente-Rodríguez M, et al. Among authors: gomez nicola d. J Neuroinflammation. 2023 Apr 9;20(1):92. doi: 10.1186/s12974-023-02769-y. J Neuroinflammation. 2023. PMID: 37032328 Free PMC article.
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.
Schubert JJ, Veronese M, Fryer TD, Manavaki R, Kitzbichler MG, Nettis MA, Mondelli V, Pariante CM, Bullmore ET; NIMA Consortium; Turkheimer FE. Schubert JJ, et al. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Jul;6(7):716-724. doi: 10.1016/j.bpsc.2020.12.017. Epub 2021 Jan 28. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021. PMID: 33515765 Free PMC article.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium; Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Mancuso R, et al. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. Brain. 2019. PMID: 31504240 Free PMC article.
The use of human neurons for novel drug discovery in dementia research.
Vargas-Caballero M, Willaime-Morawek S, Gomez-Nicola D, Perry VH, Bulters D, Mudher A. Vargas-Caballero M, et al. Expert Opin Drug Discov. 2016;11(4):355-67. doi: 10.1517/17460441.2016.1154528. Epub 2016 Mar 1. Expert Opin Drug Discov. 2016. PMID: 26878555 Review.
68 results