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Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease.
Vicente-Rodríguez M, Mancuso R, Peris-Yague A, Simmons C; NIMA Consortium; Gómez-Nicola D, Perry VH, Turkheimer F, Lovestone S, Parker CA, Cash D. Vicente-Rodríguez M, et al. Among authors: parker ca. J Neuroinflammation. 2023 Apr 9;20(1):92. doi: 10.1186/s12974-023-02769-y. J Neuroinflammation. 2023. PMID: 37032328 Free PMC article.
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Mancuso R, Fryatt G, Cleal M, Obst J, Pipi E, Monzón-Sandoval J, Ribe E, Winchester L, Webber C, Nevado A, Jacobs T, Austin N, Theunis C, Grauwen K, Daniela Ruiz E, Mudher A, Vicente-Rodriguez M, Parker CA, Simmons C, Cash D, Richardson J; NIMA Consortium; Jones DNC, Lovestone S, Gómez-Nicola D, Perry VH. Mancuso R, et al. Among authors: parker ca. Brain. 2019 Oct 1;142(10):3243-3264. doi: 10.1093/brain/awz241. Brain. 2019. PMID: 31504240 Free PMC article.
A Modest Increase in 11C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index.
Schubert JJ, Veronese M, Fryer TD, Manavaki R, Kitzbichler MG, Nettis MA, Mondelli V, Pariante CM, Bullmore ET; NIMA Consortium; Turkheimer FE. Schubert JJ, et al. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Jul;6(7):716-724. doi: 10.1016/j.bpsc.2020.12.017. Epub 2021 Jan 28. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021. PMID: 33515765 Free PMC article.
Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load.
Calsolaro V, Matthews PM, Donat CK, Livingston NR, Femminella GD, Guedes SS, Myers J, Fan Z, Tyacke RJ, Venkataraman AV, Perneczky R, Gunn R, Rabiner EA, Gentleman S, Parker CA, Murphy PS, Wren PB, Hinz R, Sastre M, Nutt DJ, Edison P. Calsolaro V, et al. Among authors: parker ca. Mol Psychiatry. 2021 Oct;26(10):5848-5855. doi: 10.1038/s41380-021-01193-z. Epub 2021 Jul 15. Mol Psychiatry. 2021. PMID: 34267329 Free PMC article.
Imidazoline-I2 PET Tracers in Neuroimaging.
Parker CA, Nutt DJ, Tyacke RJ. Parker CA, et al. Int J Mol Sci. 2023 Jun 6;24(12):9787. doi: 10.3390/ijms24129787. Int J Mol Sci. 2023. PMID: 37372936 Free PMC article. Review.
An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28.
Owen DR, Yeo AJ, Gunn RN, Song K, Wadsworth G, Lewis A, Rhodes C, Pulford DJ, Bennacef I, Parker CA, StJean PL, Cardon LR, Mooser VE, Matthews PM, Rabiner EA, Rubio JP. Owen DR, et al. Among authors: parker ca. J Cereb Blood Flow Metab. 2012 Jan;32(1):1-5. doi: 10.1038/jcbfm.2011.147. Epub 2011 Oct 19. J Cereb Blood Flow Metab. 2012. PMID: 22008728 Free PMC article.
Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008.
Kealey S, Turner EM, Husbands SM, Salinas CA, Jakobsen S, Tyacke RJ, Nutt DJ, Parker CA, Gee AD. Kealey S, et al. Among authors: parker ca. J Nucl Med. 2013 Jan;54(1):139-44. doi: 10.2967/jnumed.112.108258. Epub 2012 Dec 5. J Nucl Med. 2013. PMID: 23223380 Free article.
124 results