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Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank, Million Veteran Program, PsycheMERGE Substance Use Disorder Workgroup; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Toikumo S, et al. Among authors: hatoum as. medRxiv [Preprint]. 2023 Sep 18:2023.03.27.23287713. doi: 10.1101/2023.03.27.23287713. medRxiv. 2023. PMID: 37034728 Free PMC article. Updated. Preprint.
A large-scale genome-wide association study meta-analysis of cannabis use disorder.
Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S; Psychiatric Genomics Consortium Substance Use Disorders Workgroup; Davis LK, Bogdan R, Geler… See abstract for full author list ➔ Johnson EC, et al. Among authors: hatoum as. Lancet Psychiatry. 2020 Dec;7(12):1032-1045. doi: 10.1016/S2215-0366(20)30339-4. Epub 2020 Oct 20. Lancet Psychiatry. 2020. PMID: 33096046 Free PMC article.
Prenatal cannabis exposure is associated with localized brain differences that partially mediate associations with increased adolescent psychopathology.
Baranger DA, Miller AP, Gorelik AJ, Paul SE, Hatoum AS, Johnson EC, Colbert SM, Smyser CD, Rogers CE, Bijsterbosch JD, Agrawal A, Bogdan R. Baranger DA, et al. Among authors: hatoum as. medRxiv [Preprint]. 2023 Oct 17:2023.09.19.23295792. doi: 10.1101/2023.09.19.23295792. medRxiv. 2023. PMID: 37790406 Free PMC article. Preprint.
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.
Paul SE, Baranger DAA, Johnson EC, Jackson JJ, Gorelik AJ, Miller AP, Hatoum AS, Thompson WK, Strube M, Dick DM, Kamarajan C, Kramer JR, Plawecki MH, Chan G, Anokhin AP, Chorlian DB, Kinreich S, Meyers JL, Porjesz B, Edenberg HJ, Agrawal A, Bucholz KK, Bogdan R. Paul SE, et al. Among authors: hatoum as. Psychol Med. 2024 May 9:1-14. doi: 10.1017/S003329172400076X. Online ahead of print. Psychol Med. 2024. PMID: 38721768
Two common and distinct forms of variation in human functional brain networks.
Dworetsky A, Seitzman BA, Adeyemo B, Nielsen AN, Hatoum AS, Smith DM, Nichols TE, Neta M, Petersen SE, Gratton C. Dworetsky A, et al. Among authors: hatoum as. Nat Neurosci. 2024 Apr 30. doi: 10.1038/s41593-024-01618-2. Online ahead of print. Nat Neurosci. 2024. PMID: 38689142
Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.
Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M; Penn Medicine BioBank; Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Toikumo S, et al. Among authors: hatoum as. Nat Hum Behav. 2024 Apr 17. doi: 10.1038/s41562-024-01851-6. Online ahead of print. Nat Hum Behav. 2024. PMID: 38632388
A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.
Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS; 23andMe, Inc. Research Team; Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. Jennings MV, et al. Among authors: hatoum as. EBioMedicine. 2024 May;103:105086. doi: 10.1016/j.ebiom.2024.105086. Epub 2024 Apr 4. EBioMedicine. 2024. PMID: 38580523 Free PMC article.
60 results