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Understanding cell fate acquisition in stem-cell-derived pancreatic islets using single-cell multiome-inferred regulomes.
Zhu H, Wang G, Nguyen-Ngoc KV, Kim D, Miller M, Goss G, Kovsky J, Harrington AR, Saunders DC, Hopkirk AL, Melton R, Powers AC, Preissl S, Spagnoli FM, Gaulton KJ, Sander M. Zhu H, et al. Among authors: powers ac. Dev Cell. 2023 May 8;58(9):727-743.e11. doi: 10.1016/j.devcel.2023.03.011. Epub 2023 Apr 10. Dev Cell. 2023. PMID: 37040771 Free PMC article.
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.
Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. Arda HE, et al. Among authors: powers ac. Cell Metab. 2016 May 10;23(5):909-20. doi: 10.1016/j.cmet.2016.04.002. Epub 2016 Apr 28. Cell Metab. 2016. PMID: 27133132 Free PMC article.
Replicative capacity of β-cells and type 1 diabetes.
Saunders D, Powers AC. Saunders D, et al. Among authors: powers ac. J Autoimmun. 2016 Jul;71:59-68. doi: 10.1016/j.jaut.2016.03.014. Epub 2016 Apr 28. J Autoimmun. 2016. PMID: 27133598 Free PMC article. Review.
Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.
Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M, Kislinger T, Nostro MC. Cogger KF, et al. Among authors: powers ac. Nat Commun. 2017 Aug 24;8(1):331. doi: 10.1038/s41467-017-00561-0. Nat Commun. 2017. PMID: 28835709 Free PMC article.
α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.
Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC. Brissova M, et al. Among authors: powers ac. Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032. Cell Rep. 2018. PMID: 29514095 Free PMC article.
Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.
Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC. Saunders DC, et al. Among authors: powers ac. Cell Metab. 2019 Mar 5;29(3):745-754.e4. doi: 10.1016/j.cmet.2018.10.007. Epub 2018 Nov 15. Cell Metab. 2019. PMID: 30449685 Free PMC article.
Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.
Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC. Haliyur R, et al. Among authors: powers ac. J Clin Invest. 2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994. Epub 2018 Dec 3. J Clin Invest. 2019. PMID: 30507613 Free PMC article.
Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.
Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H. Moon JH, et al. Among authors: powers ac. Diabetes. 2020 Feb;69(2):205-214. doi: 10.2337/db19-0546. Epub 2019 Dec 5. Diabetes. 2020. PMID: 31806625 Free PMC article.
Integrated human pseudoislet system and microfluidic platform demonstrate differences in GPCR signaling in islet cells.
Walker JT, Haliyur R, Nelson HA, Ishahak M, Poffenberger G, Aramandla R, Reihsmann C, Luchsinger JR, Saunders DC, Wang P, Garcia-Ocaña A, Bottino R, Agarwal A, Powers AC, Brissova M. Walker JT, et al. Among authors: powers ac. JCI Insight. 2020 May 21;5(10):e137017. doi: 10.1172/jci.insight.137017. JCI Insight. 2020. PMID: 32352931 Free PMC article.
219 results