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A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration.
Clark R, Lee SS, Du R, Wang Y, Kneepkens SCM, Charng J, Huang Y, Hunter ML, Jiang C, Tideman JWL, Melles RB, Klaver CCW, Mackey DA, Williams C, Choquet H, Ohno-Matsui K, Guggenheim JA; CREAM Consortium; UK Biobank Eye and Vision Consortium. Clark R, et al. EBioMedicine. 2023 May;91:104551. doi: 10.1016/j.ebiom.2023.104551. Epub 2023 Apr 11. EBioMedicine. 2023. PMID: 37055258 Free PMC article.
Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia.
Plotnikov D, Cui J, Clark R, Wedenoja J, Pärssinen O, Tideman JWL, Jonas JB, Wang Y, Rudan I, Young TL, Mackey DA, Terry L, Williams C, Guggenheim JA; UK Biobank Eye and Vision Consortium and the CREAM Consortium. Plotnikov D, et al. Among authors: clark r. Invest Ophthalmol Vis Sci. 2021 Oct 4;62(13):24. doi: 10.1167/iovs.62.13.24. Invest Ophthalmol Vis Sci. 2021. PMID: 34698770 Free PMC article.
Whole exome sequence analysis in 51 624 participants identifies novel genes and variants associated with refractive error and myopia.
Guggenheim JA, Clark R, Cui J, Terry L, Patasova K, Haarman AEG, Musolf AM, Verhoeven VJM, Klaver CCW, Bailey-Wilson JE, Hysi PG, Williams C; CREAM Consortium; UK Biobank Eye Vision Consortium. Guggenheim JA, et al. Among authors: clark r. Hum Mol Genet. 2022 Jun 4;31(11):1909-1919. doi: 10.1093/hmg/ddac004. Hum Mol Genet. 2022. PMID: 35022715 Free PMC article.
Assessing the contribution of genetic nurture to refractive error.
Guggenheim JA, Clark R, Zayats T, Williams C; UK Biobank Eye and Vision Consortium. Guggenheim JA, et al. Among authors: clark r. Eur J Hum Genet. 2022 Nov;30(11):1226-1232. doi: 10.1038/s41431-022-01126-6. Epub 2022 May 27. Eur J Hum Genet. 2022. PMID: 35618892 Free PMC article.
Time Spent Outdoors Partly Accounts for the Effect of Education on Myopia.
Clark R, Kneepkens SCM, Plotnikov D, Shah RL, Huang Y, Tideman JWL, Klaver CCW, Atan D, Williams C, Guggenheim JA; UK Biobank Eye and Vision Consortium. Clark R, et al. Invest Ophthalmol Vis Sci. 2023 Nov 1;64(14):38. doi: 10.1167/iovs.64.14.38. Invest Ophthalmol Vis Sci. 2023. PMID: 38010695 Free PMC article.
The potential and value of objective eye tracking in the ophthalmology clinic.
Clark R, Blundell J, Dunn MJ, Erichsen JT, Giardini ME, Gottlob I, Harris C, Lee H, Mcilreavy L, Olson A, Self JE, Vinuela-Navarro V, Waddington J, Woodhouse JM, Gilchrist ID, Williams C. Clark R, et al. Eye (Lond). 2019 Aug;33(8):1200-1202. doi: 10.1038/s41433-019-0417-z. Epub 2019 Apr 8. Eye (Lond). 2019. PMID: 30962545 Free PMC article. Review. No abstract available.
7,259 results