Feldman JL - Search Results

1

Cryo-EM structure of the human Sirtuin 6-nucleosome complex.

Chio US, Rechiche O, Bryll AR, Zhu J, Leith EM, Feldman JL, Peterson CL, Tan S, Armache JP. Chio US, et al. Among authors: feldman jl. Sci Adv. 2023 Apr 14;9(15):eadf7586. doi: 10.1126/sciadv.adf7586. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058572 Free PMC article.

2

Yeast Sirtuin Family Members Maintain Transcription Homeostasis to Ensure Genome Stability.

Feldman JL, Peterson CL. Feldman JL, et al. Cell Rep. 2019 Jun 4;27(10):2978-2989.e5. doi: 10.1016/j.celrep.2019.05.009. Cell Rep. 2019. PMID: 31167142 Free PMC article.

3

Multivalent interactions drive nucleosome binding and efficient chromatin deacetylation by SIRT6.

Liu WH, Zheng J, Feldman JL, Klein MA, Kuznetsov VI, Peterson CL, Griffin PR, Denu JM. Liu WH, et al. Among authors: feldman jl. Nat Commun. 2020 Oct 16;11(1):5244. doi: 10.1038/s41467-020-19018-y. Nat Commun. 2020. PMID: 33067423 Free PMC article.

4

Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins.

Feldman JL, Baeza J, Denu JM. Feldman JL, et al. J Biol Chem. 2013 Oct 25;288(43):31350-6. doi: 10.1074/jbc.C113.511261. Epub 2013 Sep 18. J Biol Chem. 2013. PMID: 24052263 Free PMC article.

5

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer.

Kugel S, Feldman JL, Klein MA, Silberman DM, Sebastián C, Mermel C, Dobersch S, Clark AR, Getz G, Denu JM, Mostoslavsky R. Kugel S, et al. Among authors: feldman jl. Cell Rep. 2015 Oct 20;13(3):479-488. doi: 10.1016/j.celrep.2015.09.022. Epub 2015 Oct 8. Cell Rep. 2015. PMID: 26456828 Free PMC article.

6

Sirtuin catalysis and regulation.

Feldman JL, Dittenhafer-Reed KE, Denu JM. Feldman JL, et al. J Biol Chem. 2012 Dec 14;287(51):42419-27. doi: 10.1074/jbc.R112.378877. Epub 2012 Oct 18. J Biol Chem. 2012. PMID: 23086947 Free PMC article. Review.

7

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

Dominy JE Jr, Lee Y, Jedrychowski MP, Chim H, Jurczak MJ, Camporez JP, Ruan HB, Feldman J, Pierce K, Mostoslavsky R, Denu JM, Clish CB, Yang X, Shulman GI, Gygi SP, Puigserver P. Dominy JE Jr, et al. Mol Cell. 2012 Dec 28;48(6):900-13. doi: 10.1016/j.molcel.2012.09.030. Epub 2012 Nov 8. Mol Cell. 2012. PMID: 23142079 Free PMC article.

8

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.

Feldman JL, Dittenhafer-Reed KE, Kudo N, Thelen JN, Ito A, Yoshida M, Denu JM. Feldman JL, et al. Biochemistry. 2015 May 19;54(19):3037-3050. doi: 10.1021/acs.biochem.5b00150. Epub 2015 May 4. Biochemistry. 2015. PMID: 25897714 Free PMC article.

9

Structure and biochemical functions of SIRT6.

Pan PW, Feldman JL, Devries MK, Dong A, Edwards AM, Denu JM. Pan PW, et al. Among authors: feldman jl. J Biol Chem. 2011 Apr 22;286(16):14575-87. doi: 10.1074/jbc.M111.218990. Epub 2011 Mar 1. J Biol Chem. 2011. PMID: 21362626 Free PMC article.

10

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output.

Lessenger AT, Swaffer MP, Skotheim JM, Feldman JL. Lessenger AT, et al. Among authors: feldman jl. bioRxiv [Preprint]. 2024 Mar 27:2024.03.25.586714. doi: 10.1101/2024.03.25.586714. bioRxiv. 2024. PMID: 38585999 Free PMC article. Preprint.

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