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Randomization, design and analysis for interdependency in aging research: no person or mouse is an island.
Chusyd DE, Austad SN, Dickinson SL, Ejima K, Gadbury GL, Golzarri-Arroyo L, Holden RJ, Jamshidi-Naeini Y, Landsittel D, Mehta T, Oakes JM, Owora AH, Pavela G, Rojo J, Sandel MW, Smith DL Jr, Vorland CJ, Xun P, Zoh R, Allison DB. Chusyd DE, et al. Among authors: ejima k. Nat Aging. 2022 Dec;2(12):1101-1111. doi: 10.1038/s43587-022-00333-6. Epub 2022 Dec 22. Nat Aging. 2022. PMID: 37063472 Free PMC article.
Observational research rigour alone does not justify causal inference.
Ejima K, Li P, Smith DL Jr, Nagy TR, Kadish I, van Groen T, Dawson JA, Yang Y, Patki A, Allison DB. Ejima K, et al. Eur J Clin Invest. 2016 Dec;46(12):985-993. doi: 10.1111/eci.12681. Epub 2016 Oct 28. Eur J Clin Invest. 2016. PMID: 27711975 Free PMC article.
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice.
Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM. Mao K, et al. Among authors: ejima k. Nat Commun. 2018 Jun 19;9(1):2394. doi: 10.1038/s41467-018-04805-5. Nat Commun. 2018. PMID: 29921922 Free PMC article.
Senolytics improve physical function and increase lifespan in old age.
Xu M, Pirtskhalava T, Farr JN, Weigand BM, Palmer AK, Weivoda MM, Inman CL, Ogrodnik MB, Hachfeld CM, Fraser DG, Onken JL, Johnson KO, Verzosa GC, Langhi LGP, Weigl M, Giorgadze N, LeBrasseur NK, Miller JD, Jurk D, Singh RJ, Allison DB, Ejima K, Hubbard GB, Ikeno Y, Cubro H, Garovic VD, Hou X, Weroha SJ, Robbins PD, Niedernhofer LJ, Khosla S, Tchkonia T, Kirkland JL. Xu M, et al. Among authors: ejima k. Nat Med. 2018 Aug;24(8):1246-1256. doi: 10.1038/s41591-018-0092-9. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988130 Free PMC article.
219 results