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Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures.
Rausch T, Snajder R, Leger A, Simovic M, Giurgiu M, Villacorta L, Henssen AG, Fröhling S, Stegle O, Birney E, Bonder MJ, Ernst A, Korbel JO. Rausch T, et al. Among authors: henssen ag. Cell Genom. 2023 Mar 22;3(4):100281. doi: 10.1016/j.xgen.2023.100281. eCollection 2023 Apr 12. Cell Genom. 2023. PMID: 37082141 Free PMC article.
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells.
Chamorro González R, Conrad T, Stöber MC, Xu R, Giurgiu M, Rodriguez-Fos E, Kasack K, Brückner L, van Leen E, Helmsauer K, Dorado Garcia H, Stefanova ME, Hung KL, Bei Y, Schmelz K, Lodrini M, Mundlos S, Chang HY, Deubzer HE, Sauer S, Eggert A, Schulte JH, Schwarz RF, Haase K, Koche RP, Henssen AG. Chamorro González R, et al. Among authors: henssen ag. Nat Genet. 2023 May;55(5):880-890. doi: 10.1038/s41588-023-01386-y. Epub 2023 May 4. Nat Genet. 2023. PMID: 37142849 Free PMC article.
Mutational topography reflects clinical neuroblastoma heterogeneity.
Rodriguez-Fos E, Planas-Fèlix M, Burkert M, Puiggròs M, Toedling J, Thiessen N, Blanc E, Szymansky A, Hertwig F, Ishaque N, Beule D, Torrents D, Eggert A, Koche RP, Schwarz RF, Haase K, Schulte JH, Henssen AG. Rodriguez-Fos E, et al. Among authors: henssen ag. Cell Genom. 2023 Sep 7;3(10):100402. doi: 10.1016/j.xgen.2023.100402. eCollection 2023 Oct 11. Cell Genom. 2023. PMID: 37868040 Free PMC article.
Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer.
Bei Y, Bramé L, Kirchner M, Fritsche-Guenther R, Kunz S, Bhattacharya A, Rusu MC, Gürgen D, Dubios FPB, Köppke JKC, Proba J, Wittstruck N, Sidorova OA, Chamorro González R, Dorado Garcia H, Brückner L, Xu R, Giurgiu M, Rodriguez-Fos E, Yu Q, Spanjaard B, Koche RP, Schmitt CA, Schulte JH, Eggert A, Haase K, Kirwan J, Hagemann AIH, Mertins P, Dörr JR, Henssen AG. Bei Y, et al. Among authors: henssen ag. Cancer Discov. 2024 Mar 1;14(3):492-507. doi: 10.1158/2159-8290.CD-23-1189. Cancer Discov. 2024. PMID: 38197697 Free PMC article.
Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing.
Szymansky A, Kruetzfeldt LM, Heukamp LC, Hertwig F, Theissen J, Deubzer HE, Willing EM, Menon R, Fuchs S, Thole T, Schulte S, Schmelz K, Künkele A, Lang P, Fuchs J, Eggert A, Eckert C, Fischer M, Henssen AG, Rodriguez-Fos E, Schulte JH. Szymansky A, et al. Among authors: henssen ag. J Pers Med. 2021 Jul 22;11(8):691. doi: 10.3390/jpm11080691. J Pers Med. 2021. PMID: 34442335 Free PMC article.
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH.
Hung KL, Luebeck J, Dehkordi SR, Colón CI, Li R, Wong IT, Coruh C, Dharanipragada P, Lomeli SH, Weiser NE, Moriceau G, Zhang X, Bailey C, Houlahan KE, Yang W, González RC, Swanton C, Curtis C, Jamal-Hanjani M, Henssen AG, Law JA, Greenleaf WJ, Lo RS, Mischel PS, Bafna V, Chang HY. Hung KL, et al. Among authors: henssen ag. Nat Genet. 2022 Nov;54(11):1746-1754. doi: 10.1038/s41588-022-01190-0. Epub 2022 Oct 17. Nat Genet. 2022. PMID: 36253572 Free PMC article.
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma.
Helmsauer K, Valieva ME, Ali S, Chamorro González R, Schöpflin R, Röefzaad C, Bei Y, Dorado Garcia H, Rodriguez-Fos E, Puiggròs M, Kasack K, Haase K, Keskeny C, Chen CY, Kuschel LP, Euskirchen P, Heinrich V, Robson MI, Rosswog C, Toedling J, Szymansky A, Hertwig F, Fischer M, Torrents D, Eggert A, Schulte JH, Mundlos S, Henssen AG, Koche RP. Helmsauer K, et al. Among authors: henssen ag. Nat Commun. 2020 Nov 16;11(1):5823. doi: 10.1038/s41467-020-19452-y. Nat Commun. 2020. PMID: 33199677 Free PMC article.
63 results