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Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus.
Chen DY, Turcinovic J, Feng S, Kenney DJ, Chin CV, Choudhary MC, Conway HL, Semaan M, Close BJ, Tavares AH, Seitz S, Khan N, Kapell S, Crossland NA, Li JZ, Douam F, Baker SC, Connor JH, Saeed M. Chen DY, et al. Among authors: saeed m. iScience. 2023 May 19;26(5):106634. doi: 10.1016/j.isci.2023.106634. Epub 2023 Apr 10. iScience. 2023. PMID: 37095858 Free PMC article.
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction.
Ejemel M, Li Q, Hou S, Schiller ZA, Tree JA, Wallace A, Amcheslavsky A, Kurt Yilmaz N, Buttigieg KR, Elmore MJ, Godwin K, Coombes N, Toomey JR, Schneider R, Ramchetty AS, Close BJ, Chen DY, Conway HL, Saeed M, Ganesa C, Carroll MW, Cavacini LA, Klempner MS, Schiffer CA, Wang Y. Ejemel M, et al. Among authors: saeed m. Nat Commun. 2020 Aug 21;11(1):4198. doi: 10.1038/s41467-020-18058-8. Nat Commun. 2020. PMID: 32826914 Free PMC article.
Defining the proteolytic landscape during enterovirus infection.
Saeed M, Kapell S, Hertz NT, Wu X, Bell K, Ashbrook AW, Mark MT, Zebroski HA, Neal ML, Flodström-Tullberg M, MacDonald MR, Aitchison JD, Molina H, Rice CM. Saeed M, et al. PLoS Pathog. 2020 Sep 30;16(9):e1008927. doi: 10.1371/journal.ppat.1008927. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32997711 Free PMC article.
SARS-CoV-2 desensitizes host cells to interferon through inhibition of the JAK-STAT pathway.
Chen DY, Khan N, Close BJ, Goel RK, Blum B, Tavares AH, Kenney D, Conway HL, Ewoldt JK, Kapell S, Chitalia VC, Crossland NA, Chen CS, Kotton DN, Baker SC, Connor JH, Douam F, Emili A, Saeed M. Chen DY, et al. Among authors: saeed m. bioRxiv [Preprint]. 2020 Oct 28:2020.10.27.358259. doi: 10.1101/2020.10.27.358259. bioRxiv. 2020. PMID: 33140044 Free PMC article. Preprint.
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2.
Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Hekman RM, et al. Among authors: saeed m. Mol Cell. 2020 Dec 17;80(6):1104-1122.e9. doi: 10.1016/j.molcel.2020.11.028. Epub 2020 Nov 19. Mol Cell. 2020. PMID: 33259812 Free PMC article.
Fatal neuroinvasion and SARS-CoV-2 tropism in K18-hACE2 mice is partially independent on hACE2 expression.
Carossino M, Montanaro P, O'Connell A, Kenney D, Gertje H, Grosz K, Ericsson M, Huber BR, Subramaniam S, Kirkland TA, Walker JR, Francis KP, Klose AD, Paragas N, Kurnick S, Bosmann M, Saeed M, Balasuriya U, Douam F, Crossland N. Carossino M, et al. Among authors: saeed m. bioRxiv [Preprint]. 2021 Sep 23:2021.01.13.425144. doi: 10.1101/2021.01.13.425144. bioRxiv. 2021. PMID: 33469581 Free PMC article. Updated. Preprint.
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication.
Loffredo M, Lucero H, Chen DY, O'Connell A, Bergqvist S, Munawar A, Bandara A, De Graef S, Weeks SD, Douam F, Saeed M, Munawar AH. Loffredo M, et al. Among authors: saeed m. Sci Rep. 2021 Mar 8;11(1):5433. doi: 10.1038/s41598-021-84782-w. Sci Rep. 2021. PMID: 33686143 Free PMC article.
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation.
Sanders DW, Jumper CC, Ackerman PJ, Bracha D, Donlic A, Kim H, Kenney D, Castello-Serrano I, Suzuki S, Tamura T, Tavares AH, Saeed M, Holehouse AS, Ploss A, Levental I, Douam F, Padera RF, Levy BD, Brangwynne CP. Sanders DW, et al. Among authors: saeed m. Elife. 2021 Apr 23;10:e65962. doi: 10.7554/eLife.65962. Elife. 2021. PMID: 33890572 Free PMC article.
DNA templates with blocked long 3' end single-stranded overhangs (BL3SSO) promote bona fide Cas9-stimulated homology-directed repair of long transgenes into endogenous gene loci.
Bandyopadhyay S, Douglass J, Kapell S, Khan N, Feitosa-Suntheimer F, Klein JA, Temple J, Brown-Culbertson J, Tavares AH, Saeed M, Lau NC. Bandyopadhyay S, et al. Among authors: saeed m. G3 (Bethesda). 2021 Aug 7;11(8):jkab169. doi: 10.1093/g3journal/jkab169. G3 (Bethesda). 2021. PMID: 33989385 Free PMC article.
2,326 results