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Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.
La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Peláez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. La CC, et al. Among authors: conway em. Nat Commun. 2023 Apr 26;14(1):2177. doi: 10.1038/s41467-023-37709-0. Nat Commun. 2023. PMID: 37100783 Free PMC article.
Polyphosphate suppresses complement via the terminal pathway.
Wat JM, Foley JH, Krisinger MJ, Ocariza LM, Lei V, Wasney GA, Lameignere E, Strynadka NC, Smith SA, Morrissey JH, Conway EM. Wat JM, et al. Among authors: conway em. Blood. 2014 Jan 30;123(5):768-76. doi: 10.1182/blood-2013-07-515726. Epub 2013 Dec 13. Blood. 2014. PMID: 24335501 Free PMC article.
Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor.
Wijeyewickrema LC, Lameignere E, Hor L, Duncan RC, Shiba T, Travers RJ, Kapopara PR, Lei V, Smith SA, Kim H, Morrissey JH, Pike RN, Conway EM. Wijeyewickrema LC, et al. Among authors: conway em. Blood. 2016 Sep 29;128(13):1766-76. doi: 10.1182/blood-2016-02-699561. Epub 2016 Jun 23. Blood. 2016. PMID: 27338096 Free PMC article.
Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.
Cines DB, Yarovoi SV, Zaitsev SV, Lebedeva T, Rauova L, Poncz M, Arepally GM, Khandelwal S, Stepanova V, Rux AH, Cuker A, Guo C, Ocariza LM, Travers RJ, Smith SA, Kim H, Morrissey JH, Conway EM. Cines DB, et al. Among authors: conway em. Blood Adv. 2016 Nov 22;1(1):62-74. doi: 10.1182/bloodadvances.2016000877. eCollection 2016 Nov 29. Blood Adv. 2016. PMID: 29296696 Free PMC article.
Understanding COVID-19-associated coagulopathy.
Conway EM, Mackman N, Warren RQ, Wolberg AS, Mosnier LO, Campbell RA, Gralinski LE, Rondina MT, van de Veerdonk FL, Hoffmeister KM, Griffin JH, Nugent D, Moon K, Morrissey JH. Conway EM, et al. Nat Rev Immunol. 2022 Oct;22(10):639-649. doi: 10.1038/s41577-022-00762-9. Epub 2022 Aug 5. Nat Rev Immunol. 2022. PMID: 35931818 Free PMC article. Review.
151 results