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Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.
La CC, Smith SA, Vappala S, Adili R, Luke CE, Abbina S, Luo HD, Chafeeva I, Drayton M, Creagh LA, de Guadalupe Jaraquemada-Peláez M, Rhoads N, Kalathottukaren MT, Henke PK, Straus SK, Du C, Conway EM, Holinstat M, Haynes CA, Morrissey JH, Kizhakkedathu JN. La CC, et al. Among authors: holinstat m. Nat Commun. 2023 Apr 26;14(1):2177. doi: 10.1038/s41467-023-37709-0. Nat Commun. 2023. PMID: 37100783 Free PMC article.
The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.
Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF. Whitley MJ, et al. Among authors: holinstat m. J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22. J Thromb Haemost. 2018. PMID: 30347494 Free PMC article.
The emerging role of oxylipins in thrombosis and diabetes.
Tourdot BE, Ahmed I, Holinstat M. Tourdot BE, et al. Among authors: holinstat m. Front Pharmacol. 2014 Jan 7;4:176. doi: 10.3389/fphar.2013.00176. eCollection 2014 Jan 7. Front Pharmacol. 2014. PMID: 24432004 Free PMC article. Review.
RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability.
Mehta D, Ahmmed GU, Paria BC, Holinstat M, Voyno-Yasenetskaya T, Tiruppathi C, Minshall RD, Malik AB. Mehta D, et al. Among authors: holinstat m. J Biol Chem. 2003 Aug 29;278(35):33492-500. doi: 10.1074/jbc.M302401200. Epub 2003 May 22. J Biol Chem. 2003. PMID: 12766172 Free article.
We can do it together: PAR1/PAR2 heterodimer signaling in VSMCs.
Pawlinski R, Holinstat M. Pawlinski R, et al. Among authors: holinstat m. Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2775-6. doi: 10.1161/ATVBAHA.111.238865. Arterioscler Thromb Vasc Biol. 2011. PMID: 22096094 Free PMC article. No abstract available.
Newer agents in antiplatelet therapy: a review.
Yeung J, Holinstat M. Yeung J, et al. Among authors: holinstat m. J Blood Med. 2012;3:33-42. doi: 10.2147/JBM.S25421. Epub 2012 Jun 25. J Blood Med. 2012. PMID: 22792011 Free PMC article.
107 results